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A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram

NCT ID: NCT01217346

Last Updated: 2013-08-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-02-28

Study Completion Date

2012-12-31

Brief Summary

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Cardiac syndrome X consists of a triad of chest pain, abnormal exercise stress testing and normal coronary angiogram, and is hypothesized to be related to endothelial dysfunction. Endothelial dysfunction is also reported to be linked to obstructive sleep apnea. While chest pain can be one of potential presenting symptoms of obstructive sleep apnea, the investigators hypothesize that obstructive sleep apnea is common in subjects with cardiac syndrome X.

Detailed Description

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Conditions

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Obstructive Sleep Apnea Cardiac Syndrome X Endothelial Dysfunction

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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cardiac syndrome X

subjects fulfilling the clinical triad of cardiac syndrome X

no intervention is involved in this study

Intervention Type OTHER

no intervention is involved in this study

Interventions

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no intervention is involved in this study

no intervention is involved in this study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≧18 years, \< 70 years
* Symptom of chest pain occurring at least once in the preceding year
* Positive exercise treadmill test
* Negative coronary angiogram
* Mentally fit to give informed consent

Exclusion Criteria

* Mentally incapacitated persons
* Congestive heart failure
* Other potential causes of orthopnea (severe chronic obstructive pulmonary disease, persistent asthma)
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The University of Hong Kong

OTHER

Sponsor Role lead

Responsible Party

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Queen Mary Hospital, The University of Hong Kong

Principal Investigators

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Macy MS Lui

Role: PRINCIPAL_INVESTIGATOR

Queen Mary Hospital, The University of Hong Kong

Locations

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Queen Mary Hospital, The University of Hong Kong

Hong Kong, , Hong Kong

Site Status

Countries

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Hong Kong

References

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Ip MS, Tse HF, Lam B, Tsang KW, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med. 2004 Feb 1;169(3):348-53. doi: 10.1164/rccm.200306-767OC. Epub 2003 Oct 9.

Reference Type BACKGROUND
PMID: 14551167 (View on PubMed)

Loui WS, Blackshear JL, Fredrickson PA, Kaplan J. Obstructive sleep apnea manifesting as suspected angina: report of three cases. Mayo Clin Proc. 1994 Mar;69(3):244-8. doi: 10.1016/s0025-6196(12)61063-5.

Reference Type BACKGROUND
PMID: 8133662 (View on PubMed)

Philip P, Guilleminault C. ST segment abnormality, angina during sleep and obstructive sleep apnea. Sleep. 1993 Sep;16(6):558-9. doi: 10.1093/sleep/16.6.558. No abstract available.

Reference Type BACKGROUND
PMID: 8235241 (View on PubMed)

Chan HS, Chiu HF, Tse LK, Woo KS. Obstructive sleep apnea presenting with nocturnal angina, heart failure, and near-miss sudden death. Chest. 1991 Apr;99(4):1023-5. doi: 10.1378/chest.99.4.1023.

Reference Type BACKGROUND
PMID: 2009755 (View on PubMed)

Melikian N, De Bruyne B, Fearon WF, MacCarthy PA. The pathophysiology and clinical course of the normal coronary angina syndrome (cardiac syndrome X). Prog Cardiovasc Dis. 2008 Jan-Feb;50(4):294-310. doi: 10.1016/j.pcad.2007.01.003. No abstract available.

Reference Type BACKGROUND
PMID: 18156008 (View on PubMed)

Other Identifiers

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UW 09-127

Identifier Type: -

Identifier Source: org_study_id