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Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.

NCT ID: NCT02280226

Last Updated: 2018-02-07

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

17 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-04-30

Study Completion Date

2016-07-31

Brief Summary

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Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia. Further studies confirmed a massive increase of total vascular resistance as it also happens in shock to maintain perfusion of heart, lung and brain. This study is to determine the exact alterations of the cardiac function during this reaction, show the redistribution of blood volume in apnea and evaluate possible longterm effects on the central nervous system caused by repeated apnea via magnetic resonance imaging.

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Detailed Description

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Conditions

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Physiological Changes in Deliberate Apnea

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Deliberate Apnea Group

Subjects undergo maximum apnea.

Group Type EXPERIMENTAL

magnetic resonance imaging (MRI)

Intervention Type DEVICE

Interventions

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magnetic resonance imaging (MRI)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Being able to hold breath deliberately at least 4,5 minutes

Exclusion Criteria

\-
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Bonn

OTHER

Sponsor Role lead

Responsible Party

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Jonas Doerner

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Eichhorn L, Doerner J, Luetkens JA, Lunkenheimer JM, Dolscheid-Pommerich RC, Erdfelder F, Fimmers R, Nadal J, Stoffel-Wagner B, Schild HH, Hoeft A, Zur B, Naehle CP. Cardiovascular magnetic resonance assessment of acute cardiovascular effects of voluntary apnoea in elite divers. J Cardiovasc Magn Reson. 2018 Jun 18;20(1):40. doi: 10.1186/s12968-018-0455-x.

Reference Type DERIVED
PMID: 29909774 (View on PubMed)

Other Identifiers

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UBonn-MRI-heart-14

Identifier Type: -

Identifier Source: org_study_id

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