Obstructive Sleep Apnoea and Adipose Tissue Dysfunction

NCT ID: NCT02518633

Last Updated: 2017-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

15 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-03-31

Study Completion Date

2015-11-30

Brief Summary

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Dysfunctional adipose tissue predisposes to cardiovascular disease. Similarly, the risk of cardiovascular disease appears to be increased in subjects with obstructive sleep apnoea. Reduced adipose tissue oxygen availability has been described in obesity and may also be a mechanism in obstructive sleep apnoea. Hypoxia induces inflammation and fibrosis in adipose tissue which are factors contributing to cardiovascular risk. The investigators hypothesize that adipose tissue's oxygen uptake is reduced in subjects with obstructive sleep apnoea by comparing in vivo AT oxygenation and blood flow in tissue of control subjects.

Detailed Description

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Assessment includes a adipose tissue biopsy and measurement of oxygenation and blood flow by a Clarke type electrodes and non-invasive Doppler techniques.

Conditions

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Obstructive Sleep Apnoea Obesity Hypoxia

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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men with obstructive sleep apnoea

Continuous positive airway pressure devices

Continuous positive airway pressure devices

Intervention Type DEVICE

overnight use of CPAP device

control subjects

subjects with no obstructive sleep apnoea

No interventions assigned to this group

Interventions

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Continuous positive airway pressure devices

overnight use of CPAP device

Intervention Type DEVICE

Other Intervention Names

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CPAP

Eligibility Criteria

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Inclusion Criteria

* men with or without obstructive sleep apnoea

Exclusion Criteria

* weight loss interventions
* steroid use
* active smoking
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Exeter

OTHER

Sponsor Role collaborator

Royal Devon and Exeter NHS Foundation Trust

OTHER

Sponsor Role lead

Responsible Party

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Katarina Kos

Consultant Physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Katarina Kos, FRCP,PhD

Role: PRINCIPAL_INVESTIGATOR

University of Exeter

Locations

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NIHR Clinical Research Facility

Exeter, , United Kingdom

Site Status

Royal Devon and Exeter NHS Foundation Trust

Exeter, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Thorn CE, Knight B, Pastel E, McCulloch LJ, Patel B, Shore AC, Kos K. Adipose tissue is influenced by hypoxia of obstructive sleep apnea syndrome independent of obesity. Diabetes Metab. 2017 Jun;43(3):240-247. doi: 10.1016/j.diabet.2016.12.002. Epub 2017 Jan 26.

Reference Type BACKGROUND
PMID: 28131740 (View on PubMed)

Other Identifiers

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OSAadipose

Identifier Type: -

Identifier Source: org_study_id

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