Effects of Obstructive Sleep Apnea and/or Cigarette Smoking on Endothelial Function
NCT ID: NCT00957463
Last Updated: 2014-12-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
150 participants
OBSERVATIONAL
2008-06-30
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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smoker, with high apnea-hypopnea index
subjects who smoke either in the past or currently, with confirmed moderate-severe OSA
No interventions assigned to this group
smoker, mild OSA or without OSA
subjects who smoke either in the past or currently, with mild OSA or without OSA
No interventions assigned to this group
nonsmoker, with high apnea-hypopnea index
subjects who never smoke, with confirmed moderate-severe OSA
No interventions assigned to this group
nonsmoker, with mild OSA or without OSA
subjects who never smoke, with mild OSA or without OSA
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* No hospitalization in past 4 weeks
* Absence of medical comorbidity such as hypertension, ischemic heart disease, diabetes and hyperlipidemia, renal impairment, vasculitis or Raynaud's syndrome, peripheral vascular disease especially Buerger's disease, aortic disease (aortic aneurysm or dilatation), cancer, thrombocytopenia, coagulation disorder or other chronic medical illness
Exclusion Criteria
18 Years
ALL
No
Sponsors
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The University of Hong Kong
OTHER
Responsible Party
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The University of Hong Kong
Principal Investigators
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Mary SM Ip, MD
Role: PRINCIPAL_INVESTIGATOR
The University of Hong Kong
Locations
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Queen Mary Hospital
Hong Kong, , Hong Kong
Countries
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References
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Barnoya J, Glantz SA. Cardiovascular effects of secondhand smoke: nearly as large as smoking. Circulation. 2005 May 24;111(20):2684-98. doi: 10.1161/CIRCULATIONAHA.104.492215.
Kashyap R, Hock LM, Bowman TJ. Higher prevalence of smoking in patients diagnosed as having obstructive sleep apnea. Sleep Breath. 2001 Dec;5(4):167-72. doi: 10.1007/s11325-001-0167-5.
Lavie L, Lavie P. Smoking interacts with sleep apnea to increase cardiovascular risk. Sleep Med. 2008 Mar;9(3):247-53. doi: 10.1016/j.sleep.2007.03.018. Epub 2007 May 21.
El Solh AA, Akinnusi ME, Baddoura FH, Mankowski CR. Endothelial cell apoptosis in obstructive sleep apnea: a link to endothelial dysfunction. Am J Respir Crit Care Med. 2007 Jun 1;175(11):1186-91. doi: 10.1164/rccm.200611-1598OC. Epub 2007 Feb 1.
Bernhard D, Wang XL. Smoking, oxidative stress and cardiovascular diseases--do anti-oxidative therapies fail? Curr Med Chem. 2007;14(16):1703-12. doi: 10.2174/092986707781058959.
Itzhaki S, Lavie L, Pillar G, Tal G, Lavie P. Endothelial dysfunction in obstructive sleep apnea measured by peripheral arterial tone response in the finger to reactive hyperemia. Sleep. 2005 May;28(5):594-600. doi: 10.1093/sleep/28.5.594.
Other Identifiers
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UW 08-023
Identifier Type: -
Identifier Source: org_study_id