Endothelial Function Study Before Cardiovascular Surgery

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

109 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-04-30

Study Completion Date

2018-11-30

Brief Summary

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The aim of this clinical trial is to evaluate the effect of chronic obstructive pulmonary disease (COPD) and/or obstructive sleep apnea syndrome (OSAS) on the endothelial function, before cardiovascular surgery, compared to non COPD non OSAS patients undergoing also a cardiovascular surgery, by an observational physiological study.

An interim analysis will be performed when 100 patients will be included.

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Detailed Description

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Secondary objectives of this clinical trial :

* To evaluate the effect of COPD and/or OSAS on the systemic inflammation, insulin-resistance and oxydative stress, in comparison with non COPD non OSAS patients.
* To evaluate the effect of COPD and/or OSAS on the inflammation and oxydative stress of the adipose tissue, in comparison with non COPD non OSAS patients.
* To validate the STOP-BANG questionnaire in patients undergoing a cardiovascular surgery

Conditions

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Chronic Obstructive Pulmonary Disease (COPD) Obstructive Sleep Apnea Syndrome (OSAS)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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COPD+ OSAS- patients

Patients with chronic obstructive pulmonary disease (COPD) and without obstructive sleep apnea syndrome (OSAS), before planned cardiovascular surgery

No interventions assigned to this group

COPD- OSAS+ patients

Patients with obstructive sleep apnea syndrome (OSAS) and without chronic obstructive pulmonary disease (COPD), before planned cardiovascular surgery

No interventions assigned to this group

COPD+ OSAS+ patients

Patients with chronic obstructive pulmonary disease (COPD) and with obstructive sleep apnea syndrome (OSAS), with planned cardiovascular surgery

No interventions assigned to this group

COPD- OSAS- patients

Patients without chronic obstructive pulmonary disease (COPD) and without obstructive sleep apnea syndrome (OSAS), before planned cardiovascular surgery

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Men or women between 18 and 80 years old
* Patient with planned coronary artery bypass graft surgery
* Patient with planned peripheral vascular surgery
* Patient with aortic surgery

Exclusion Criteria

* Patient with aortic or mitral valvular replacement
* Patient with emergency peripheral valvular surgery
* Patient with emergency coronary artery bypass graft surgery
* Patient with evolutive malignancy disease
* Pregnant or lactating women
* Patient with inadvisable bronchodilator (used for functional respiratory) exploration

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No