Prevalence of Pulmonary Hypertension in COPD Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

117 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-03-31

Study Completion Date

2011-03-31

Brief Summary

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The prevalence of an increased pulmonary blood pressure amongst patients with chronic obstructive pulmonary disease (COPD)is unclear. So is the impact of abnormal pulmonary blood pressure on symptoms. The aim of this study is to determine the prevalence of an increased pulmonary blood pressure in 200 patients with COPD. Furthermore we will investigate if lung function test results and blood tests can predict an increased pulmonary blood pressure, and explore whether COPD patients with a high pulmonary blood pressure have more symptoms that their co-patients.

Detailed Description

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The prevalence of pulmonary hypertension in patients with chronic obstructive pulmonary disease (COPD) is unclear. The presence of an abnormally increased pulmonary blood pressure worsens the prognosis of COPD, but the patients are not currently diagnosed or treated for pulmonary hypertension. The aim of this study is to determine the prevalence of pulmonary hypertension in 200 patients with COPD and explore whether it worsens functional capacity and symptoms. Furthermore we will look into whether blood gas values, NT-proBNP, CRP and lung function test result can predict which patients are at risk of having pulmonary hypertension.

Methods: All patients will be screened by echocardiography. Those with signs of pulmonary hypertension will be admitted to right heart catheterization for direct measurements of pulmonary haemodynamics.

All patients will perform a 6 minutes walk test and spirometry. Blood levels of NT-proBNP and CRP will be measured. Life quality by the St. George Questionnaire and contacts to the health care system is also assessed. Differences in these parameters are analyzed among patients with no, moderate or severe pulmonary hypertension.

Conditions

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COPD Pulmonary Hypertension

Keywords

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COPD pulmonary hypertension NT-proBNP 6 minutes walk test

Study Design

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Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of COPD
* Prior admittance to hospital with exacerbation in COPD
* Informed consent

Exclusion Criteria

* Exacerbation in COPD less than 6 weeks before examination

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Charlotte Andersen

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Ole Hilberg, Md, Dr.med.

Role: STUDY_DIRECTOR

Aarhus Universitetshospital, Aarhus Sygehus

Locations

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Department of pulmonary diseases, Aarhus Sygehus

Aarhus, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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jnr 2007-0206

Identifier Type: -

Identifier Source: secondary_id

PreKPH-08