Lung Perfusion With Oxygenated Blood During Aortic Clamping

NCT ID: NCT01186510

Last Updated: 2013-06-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-08-31

Study Completion Date

2012-11-30

Brief Summary

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Pulmonary dysfunction presumably linked to an inflammatory response is frequent after cardiac operations using cardiopulmonary bypass (CPB) and pulmonary hypoperfusion.

Aim of the study: To evaluate the protective effect of continuous pulmonary perfusion with oxygenated blood during aortic crossclamping on the inflammatory response.

Detailed Description

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Conditions

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Postoperative Pulmonary Dysfunction

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Lung perfusion

Group Type EXPERIMENTAL

lung perfusion

Intervention Type PROCEDURE

see literature of proceeding

no lung perfusion

Group Type ACTIVE_COMPARATOR

no lung perfusion

Intervention Type PROCEDURE

see literature of proceeding

Interventions

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lung perfusion

see literature of proceeding

Intervention Type PROCEDURE

no lung perfusion

see literature of proceeding

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age 18-80 ys
* Cardiopulmonary bypass procedure
* FEV1 \<80%
* COPD \>II

Exclusion Criteria

* Emergency cases
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Johann Wolfgang Goethe University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Arndt-H. Kiessling

Head Cardiovascular Research

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Goethe University

Frankfurt am Main, , Germany

Site Status

Countries

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Germany

References

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Kiessling AH, Guo FW, Gokdemir Y, Thudt M, Reyher C, Scherer M, Beiras-Fernandez A, Moritz A. The influence of selective pulmonary perfusion on the inflammatory response and clinical outcome of patients with chronic obstructive pulmonary disease undergoing cardiopulmonary bypass. Interact Cardiovasc Thorac Surg. 2014 Jun;18(6):732-9. doi: 10.1093/icvts/ivu062. Epub 2014 Mar 14.

Reference Type DERIVED
PMID: 24632426 (View on PubMed)

Other Identifiers

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PulPer-001-Sch

Identifier Type: -

Identifier Source: org_study_id

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