Best Cardiac Output During Cardiopulmonary Bypass

NCT ID: NCT01379638

Last Updated: 2011-06-23

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2008-12-31
• Study Completion Date: 2010-01-31

Brief Summary

The purpose of this study is to determine whether the patients cardiac output measured before cardiopulmonary bypass (CPB), is more sufficient to secure the patients oxygen needs than the estimated cardiac output from Ficks principle, and thereby prevent organ failure.

Detailed Description

For more than 50 years, CPB has been used to mechanically support the functions of the heart and lungs. In early studies, systemic oxygen uptake, calculated using Ficks global principle, was used to assess the efficiency of CPB. Using this measure of efficiency, a pump flow rate in liters per minute, based on the product of the body surface area (BSA) and a constant of 2.4 was found adequate to perfuse the body during normothermia. Ficks global principle is still used together with other methods to secure adequated perfusion under CPB.

The purpose of this study is to determine whether the patients cardiac output measured before CPB, is more sufficient to secure the patients oxygen needs than the estimated cardiac output from Ficks principle, and thereby prevent organ failure.

The hypothesis is that the patients cardiac output is a better marker for the optimal cardiac output than the estimated cardiac output.

Conditions

Bypass Complications

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

cardiac output

Adult patients undergoing cardiac surgery with normothermic cardiopulmonary bypass

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• patients admitted for scheduled cardiac surgery during cardiopulmonary bypass
• Aged 18-90 years
• LVEF > 50 %
• written consent from the patients

Exclusion Criteria

• Former cerebral emboli
• Former head trauma
• known stenosis of the arteria carotis

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Aalborg University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Department of cardiothoracic surgery and anesthesiology

Principal Investigators

Bodil Steen Rasmussen, MD, PhD

Role: STUDY_DIRECTOR

Aalborg University Hospital

Locations

Alborg Hospital

Aalborg, Aalborg, Denmark

Countries

Denmark

Other Identifiers

N-20080035

Identifier Type: -

Identifier Source: org_study_id