Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)

NCT ID: NCT02405195

Last Updated: 2019-05-07

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

28 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-10-31

Study Completion Date

2016-01-31

Brief Summary

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Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). This study aims to investigate the effects of CPB on renal perfusion, filtration and oxygenation.

Detailed Description

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After approval of the regional ethics committee, patients (n=16) undergoing combined cardiac surgery procedures during normothermic CPB will be included after informed consent. Systemic and renal variables will be measured by pulmonary artery and renal vein catheters. Glomerular filtration rate (GFR) will be measured by renal extraction of 51Cr-EDTA and renal blood flow (RBF) by the infusion clearance technique for para-aminohippuric acid (PAH) corrected for by renal extraction of PAH. Repeated measures ANOVA followed by Fisher's PLSD post-hoc test were used for statistical analyses

Conditions

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Complication of Extracorporeal Circulation Renal Impairment

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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cardiopulmonary bypass

During cardiac surgery, the subjects are routinely undergoing cardiopulmonary bypass

Intervention Type PROCEDURE

Other Intervention Names

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extracorporeal circulation

Eligibility Criteria

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Inclusion Criteria

* Preserved left ventricular function (LVEF \> 50%)
* Normal preoperative S-creatinine

Exclusion Criteria

* Contraindications to radiocontrast
* Cardiac transplantation och dissection
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sahlgrenska University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Lukas Lannemyr

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sven-Erik Ricksten, Professor

Role: PRINCIPAL_INVESTIGATOR

Sahlgrenska Academy, dept of clinical science

Locations

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Department of thoracic anesthesia, Sahlgrenska University Hospital

Gothenburg, , Sweden

Site Status

Countries

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Sweden

References

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Lannemyr L, Bragadottir G, Redfors B, Ricksten SE. Effects of milrinone on renal perfusion, filtration and oxygenation in patients with acute heart failure and low cardiac output early after cardiac surgery. J Crit Care. 2020 Jun;57:225-230. doi: 10.1016/j.jcrc.2019.12.022. Epub 2020 Jan 6.

Reference Type DERIVED
PMID: 31919012 (View on PubMed)

Other Identifiers

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SahlgrenskaUHThoraxLL0

Identifier Type: -

Identifier Source: org_study_id

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