The Efficacy of Adductor-Canal-Blockade on Morphine Consumption, Pain and Mobilisation After Total Knee Arthroplasty

NCT ID: NCT01104883

Last Updated: 2011-04-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-08-31

Study Completion Date

2011-03-31

Brief Summary

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The purpose of this study is to determine whether Adductor-Canal-Blockade is effective at reducing morphine consumption and pain, and at the same time improving mobilisation after total knee arthroplasty.

Detailed Description

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Conditions

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Total Knee Arthroplasty

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Adductor-Canal-Blockade

Adductor-Canal-Blockade with ropivacaine

Group Type EXPERIMENTAL

Adductor-Canal-Blockade

Intervention Type PROCEDURE

US-guided Adductor-Canal-Blockade with ropivacaine 7,5 mg/ml

Adductor-Canal-blockade with saline

Adductor-Canal-blockade with isotonic saline

Group Type PLACEBO_COMPARATOR

Adductor-Canal-blockade with saline

Intervention Type PROCEDURE

US-guided Adductor-Canal-blockade with saline

Interventions

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Adductor-Canal-Blockade

US-guided Adductor-Canal-Blockade with ropivacaine 7,5 mg/ml

Intervention Type PROCEDURE

Adductor-Canal-blockade with saline

US-guided Adductor-Canal-blockade with saline

Intervention Type PROCEDURE

Other Intervention Names

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Naropine Postoperative pain US-guided nerve block placebo block

Eligibility Criteria

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Inclusion Criteria

* Total Knee Arthroplasty in spinal anaesthesia
* ASA 1-3
* BMI 18-40
* Written informed consent

Exclusion Criteria

* Can not cooperate to the exam
* Do not speak or understand Danish
* Drug allergy
* Alcohol or drug abuse
* Daily consumption of strong opioids
* Unable to complete the Timed Up and Go test preoperatively
Minimum Eligible Age

50 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark

Principal Investigators

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Pia Jæger, MD

Role: PRINCIPAL_INVESTIGATOR

Rigshospitalet, Denmark

Locations

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Department of Anaesthesia, Privathospitalet Hamlet, Frederiksberg, Denmark

Copenhagen, Frederiksberg, Denmark

Site Status

Department of Surgery and Anaesthesia, Glostrup Hospital

Glostrup Municipality, Glostrup, Denmark

Site Status

Countries

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Denmark

References

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Jenstrup MT, Jaeger P, Lund J, Fomsgaard JS, Bache S, Mathiesen O, Larsen TK, Dahl JB. Effects of adductor-canal-blockade on pain and ambulation after total knee arthroplasty: a randomized study. Acta Anaesthesiol Scand. 2012 Mar;56(3):357-64. doi: 10.1111/j.1399-6576.2011.02621.x. Epub 2012 Jan 4.

Reference Type DERIVED
PMID: 22221014 (View on PubMed)

Other Identifiers

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2009-017794-37

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

SM1-PJ-2009

Identifier Type: -

Identifier Source: org_study_id

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