Effect of Levosimendan on Respiratory Muscle Function in Healthy Subjects

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-04-30

Study Completion Date

2010-09-30

Brief Summary

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The purpose of this study is to investigate if levosimendan improves contractile performance of the diaphragm in healthy subjects.

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Detailed Description

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Conditions

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Respiratory Muscle Function

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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Levosimendan

Group Type ACTIVE_COMPARATOR

Levosimendan

Intervention Type DRUG

Placebo

Group Type PLACEBO_COMPARATOR

Levosimendan

Intervention Type DRUG

Interventions

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Levosimendan

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* informed consent

Exclusion Criteria

* use of any prescript medication
* chronic hiccups
* pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including diabetes and auto-immune diseases.
* pre-existent lung disease
* pre-existent cardiac disease (based on history, electrocardiography and transthoracic echocardiography)
* pregnancy, breast feeding
* upper airway / esophageal pathology
* phrenic nerve lesions
* any metals in body (pacemaker, splinters, metal stiches)

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes