Respiratory Muscle Fatigue at Different Breathing Modes

NCT ID: NCT05393115

Last Updated: 2022-05-26

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 12 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-10-01
• Study Completion Date: 2022-12-01

Brief Summary

The study aims at investigating if time to respiratory muscle fatigue and metabolism are influenced by the pressure wave form mode applied during resistive breathing.

Detailed Description

In healthy subjects fitted with a nasogastric double balloon catheter and breathing at a resistance, the investigators will measure time to failure, Borg ratings, VO2, VCO2, flow, esophageal-, gastric- and airway-pressure. This will be done during breathing at either a square wave or triangle wave pressure waveform, in random order and trials separated by >two days. Further respiratory muscle fatigue will be investigated pre and post intervention by maximal esophageal pressure generation (voluntary and with cervical magnetic stimulation).

Conditions

Healthy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Interventions

Square wave breathing

difference in time to failure from the two breathing modes

Intervention Type: OTHER

Other Intervention Names

Triangle wave breathing

Eligibility Criteria

Inclusion Criteria

• Healthy men or women
• Age ≥18 and ≤60 years
• BMI ≥ 20 and ≤30

Exclusion Criteria

• Drug addiction defined as the use of cannabis, opioids or other drugs
• Previous and present neurologic (e.g. ataxia), musculoskeletal (e.g. muscular dystrophy) or mental illnesses (e.g. schizophrenia)
• History of mechanical ventilation, COVID-19 with respiratory complications, lung cancer
• Part of lung resected
• Presence of dyspepsia/heart-burn/abdominal pain
• Presence of esophageal varices
• Presence of liver disease
• Presence of esophageal hernia
• Pregnancy
• Failure to comply with transcranial magnetic stimulation adult safety screen
• History of epilepsy, metal implants in head or jaw
• Acute or chronic lung diseases, e.g. asthma, COPD, bronchitis etc.
• Lack of ability to cooperate

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Aalborg University

OTHER

Sponsor Role: lead

Responsible Party

Mathias Krogh Poulsen

Teaching Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Mathias Krogh Poulsen

Aalborg, Danmark, Denmark

Site Status: RECRUITING

Countries

Denmark

Facility Contacts

Mathias K Poulsen

Role: primary

mkpo@hst.aau.dk

28297625 ext. 0045

Other Identifiers

Eso_pres_fatigue

Identifier Type: -

Identifier Source: org_study_id