Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

NCT ID: NCT01090375

Last Updated: 2010-03-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

EARLY_PHASE1

Study Classification

INTERVENTIONAL

Study Start Date

2008-08-31

Brief Summary

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In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.

Detailed Description

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Conditions

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Osteoarthritis Exercise

Study Design

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Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Study Groups

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Exercise

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

Non Exercise

Group Type PLACEBO_COMPARATOR

Non Exercise

Intervention Type OTHER

Interventions

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Exercise

Intervention Type OTHER

Non Exercise

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* verified osteoarthritis (x-ray)of the knee, female,

Exclusion Criteria

* dementia, inflammatory diseases, regular pain medication
Minimum Eligible Age

55 Years

Maximum Eligible Age

75 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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The Danish Rheumatism Association

OTHER

Sponsor Role collaborator

Danish Ministry of Health, Internal Affairs

UNKNOWN

Sponsor Role collaborator

Danish National Research Council

UNKNOWN

Sponsor Role collaborator

The Danish Medical Research Council

OTHER

Sponsor Role collaborator

Bispebjerg Hospital

OTHER

Sponsor Role lead

References

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Helmark IC, Mikkelsen UR, Borglum J, Rothe A, Petersen MC, Andersen O, Langberg H, Kjaer M. Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial. Arthritis Res Ther. 2010;12(4):R126. doi: 10.1186/ar3064. Epub 2010 Jul 1.

Reference Type DERIVED
PMID: 20594330 (View on PubMed)

Other Identifiers

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H-KF-306126

Identifier Type: -

Identifier Source: org_study_id

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