The Effect of Weight Loss and Exercise on Knee Osteoarthritis
NCT ID: NCT00061490
Last Updated: 2017-09-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
160 participants
INTERVENTIONAL
2002-09-30
2006-04-30
Brief Summary
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Detailed Description
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Physical activity has also been associated with pain reduction and increased mobility in individuals with knee OA and the ACR Practice Guidelines indicate that it should be included in treatment. Exercise may be especially helpful for overweight persons with knee OA as it is a potent predictor of weight loss maintenance. Though adherence to traditional exercise programs has been poor, adopting lifestyles in which exercise is accumulated throughout the day appears to be a promising new approach to physical activity. Lifestyle exercise may enhance exercise adherence by increasing options to be active and reducing time barriers. Episodic physical activity may also be preferable to continuous exercise by reducing pain and avoiding injury. The primary objective of this proposal is to evaluate the impact of weight loss and lifestyle exercise on knee osteoarthritis.
Participants will be randomly assigned to either a behavioral weight loss and exercise program or a delayed intervention group. Participants in the behavioral weight loss and exercise group will attend weekly group meetings at the Johns Hopkins Bayview Medical Center for 16 weeks. Group meetings last about 1 hour and are led by health care professionals. Participants will be taught how to lose weight and keep weight off by changing what they eat and evaluating their lifestyle. Participants will be instructed on a safe and effective diet plan (1200 calories/day for women; 1500 calories/day for men) and will be asked to increase their physical activity to about 30 minutes per day of brisk walking, most days of the week. After the 16-week program, groups will continue to meet every three months for 1 year to help sustain lifestyle changes.
The delayed intervention group will receive the program described above after a 4-month waiting period.
The primary outcome measure will be knee pain. Secondary measures include physical disability, quality of life, performance measures, and long-term adherence to behavior change.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
NONE
Study Groups
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1
16 weekly educational meetings
Behavioral weight control and lifestyle exercise
16 weekly educational meetings vs. waitlist control
2
Wait list control
No interventions assigned to this group
Interventions
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Behavioral weight control and lifestyle exercise
16 weekly educational meetings vs. waitlist control
Eligibility Criteria
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Inclusion Criteria
* Pain on \> 50 % of days in the month in one or both knees
* Difficulty with activities of daily living due to knee pain
* X-ray documenting knee OA within 1 year prior to study entry
* 15 lbs to 50 lbs overweight
Exclusion Criteria
* Major psychiatric disease
* ACR functional class IV
* Structured exercise more than once per week for 20 minutes or longer during the 3 months prior to study entry
* Anticipates moving from the area within 18 months of study entry
* Anticipates undergoing knee surgery within 1 year of study entry
* Weight loss of more than 5 kg (11 lbs) in 3 months prior to study entry
* Anorexiant or other medications known to affect metabolism
* Current or planned pregnancy
19 Years
ALL
Yes
Sponsors
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National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
NIH
Johns Hopkins University
OTHER
Responsible Party
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Principal Investigators
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Susan J. Bartlett, MD
Role: PRINCIPAL_INVESTIGATOR
Johns Hopkins University
Locations
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Johns Hopkins Bayview Medical Center
Baltimore, Maryland, United States
Countries
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Other Identifiers
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