NSAID Treatment of Patients With Osteoarthritis

NCT ID: NCT02967744

Last Updated: 2024-02-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

162 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-31

Study Completion Date

2018-02-01

Brief Summary

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The study investigates associations between pre treatment pain intensity and central pain mechanisms on the effect of 8-week treatment of NSAIDs in patients with knee osteoarthritis.

Detailed Description

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Conditions

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Osteoarthritis,Knee

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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NSAID treatment

8 weeks of NSAID treatment

Group Type EXPERIMENTAL

NSAID

Intervention Type DRUG

NSAIDs are among the most common pain treatments for patients with osteoarthritis.

Interventions

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NSAID

NSAIDs are among the most common pain treatments for patients with osteoarthritis.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosed Knee Ostoarthritis

Exclusion Criteria

* Current ulcer diagnosed by endoscope
* Asthma or other allergic reaction to NSIADs
* Kidney disease
* Myocardial infarction within the last six months
* Severe hyper tension (systolic ≥180mmHg, diastolic ≥110mmHg)
* Severe thrombocytopenia (thrombocyst count \<50x10\^9/l)
* Insufficience lever or kidney function
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aalborg University

OTHER

Sponsor Role lead

Responsible Party

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Kristian Kjær Petersen

assistant professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Center for Sensory Motor Interaction, Aalborg University

Aalborg East, , Denmark

Site Status

Countries

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Denmark

References

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Giordano R, Arendt-Nielsen L, Hertel E, Olesen AE, Petersen KK. Multifactorial Machine Learning Algorithm Integration of Pain Mechanisms Can Predict the Efficacy of 3-Week NSAID Plus Paracetamol in Patients With Painful Knee Osteoarthritis. Eur J Pain. 2025 Nov;29(10):e70140. doi: 10.1002/ejp.70140.

Reference Type DERIVED
PMID: 41020650 (View on PubMed)

Hertel E, Arendt-Nielsen L, Olesen AE, Andersen MS, Petersen KK. Quantitative sensory testing, psychological factors, and quality of life as predictors of current and future pain in patients with knee osteoarthritis. Pain. 2024 Aug 1;165(8):1719-1726. doi: 10.1097/j.pain.0000000000003194. Epub 2024 Feb 20.

Reference Type DERIVED
PMID: 38381930 (View on PubMed)

Other Identifiers

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N-20140077

Identifier Type: -

Identifier Source: org_study_id

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