Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis
NCT ID: NCT00833157
Last Updated: 2009-01-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE1
36 participants
INTERVENTIONAL
2005-02-28
2009-03-31
Brief Summary
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The investigators would like to elucidate whether treatment with glucosamine or NSAID interact with the effects of exercise in osteoarthritis patients.
Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
QUADRUPLE
Study Groups
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Glucosamine
glucosamine sulphate
Subjects are administered glucosamine-sulphate tablets of 500 mg \* 3 daily, while they are performing a strength-training program with both legs (\*3 weekly) for 12 weeks.
Ibuprofen
ibuprofen
Subjects are administered 600 mg \* 2 daily, while they are performing a strength-training program with both legs (\*3 weekly) for 12 weeks
Placebo
placebo
Subjects are administered placebo tablets, while they are performing a strength-training program (\*3 weekly) with both legs for 12 weeks
Interventions
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glucosamine sulphate
Subjects are administered glucosamine-sulphate tablets of 500 mg \* 3 daily, while they are performing a strength-training program with both legs (\*3 weekly) for 12 weeks.
ibuprofen
Subjects are administered 600 mg \* 2 daily, while they are performing a strength-training program with both legs (\*3 weekly) for 12 weeks
placebo
Subjects are administered placebo tablets, while they are performing a strength-training program (\*3 weekly) with both legs for 12 weeks
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Bilateral tibiofemoral osteoarthritis of the knee on x-ray
* American College of Rheumatology (ACR) clinical classification criteria
Exclusion Criteria
* Excess alcohol use (\> 21 alcoholic drinks per week)
* Severe overweight (BMI \> 35)
* History of injury or operation in the knee, planned knee-joint replacement, other rheumatologic diseases, previous gastric ulcer, allergy to the contents of ibuprofen or glucosamine, regular strength training prior to the inclusion
50 Years
70 Years
ALL
No
Sponsors
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Lund University
OTHER
The Danish Rheumatism Association
OTHER
Ministry of the Interior and Health, Denmark
OTHER_GOV
Bispebjerg Hospital
OTHER
Responsible Party
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Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Denmark
Principal Investigators
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Susanne G Petersen, MD
Role: PRINCIPAL_INVESTIGATOR
Bispebjerg Hospital, Institute of Sports Medicine Copenhagen
References
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Petersen SG, Beyer N, Hansen M, Holm L, Aagaard P, Mackey AL, Kjaer M. Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients. Arch Phys Med Rehabil. 2011 Aug;92(8):1185-93. doi: 10.1016/j.apmr.2011.03.009.
Petersen SG, Saxne T, Heinegard D, Hansen M, Holm L, Koskinen S, Stordal C, Christensen H, Aagaard P, Kjaer M. Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training. Osteoarthritis Cartilage. 2010 Jan;18(1):34-40. doi: 10.1016/j.joca.2009.07.004. Epub 2009 Jul 15.
Other Identifiers
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KF-01-18904
Identifier Type: -
Identifier Source: secondary_id
HIM-037
Identifier Type: -
Identifier Source: org_study_id