Knee Osteoarthritis, Aging and Metabolic Syndrome

NCT ID: NCT05955573

Last Updated: 2024-03-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-08-20

Study Completion Date

2024-08-31

Brief Summary

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Osteoarthritis (OA) is the most prevalent form of arthritis. Its pathogenesis remains poorly understood. Though historically regarded as a disease of mechanical degeneration, it is now appreciated that inflammation plays an important role in OA pathogenesis

Detailed Description

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1. Place of the study: Sohag university hospital.
2. Type of study: Cross-Sectional Observational study
3. Study period: Six months to one year The study will include Patients who met the American College of Rheumatology (ACR) clinical criteria for knee OA .

The following details will be obtained:

* Demographic data : Age ,Sex ,Marital status ,Occupation ,Residence ,Education level

,Anthropometrical measures which included waist circumference (WC) and blood pressure (BP) will be obtained,History of chronic diseases (eg; Diabetes mellites, Hypertension)
* Clinical information: Symptom and its Duration. Plain radiographs of at least one knee \[anteroposterior (A/P), lateral} will be taken.
* Laboratory findings included fasting blood sugar, serum levels of triglycerides, High-density lipoprotein cholesterol and total cholesterol.

Conditions

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Knee Osteoarthritis

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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knee osteoarthritis

Knee osteoarthritis

xray

Intervention Type DIAGNOSTIC_TEST

radiological description

Interventions

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xray

radiological description

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Patients who met the American College of Rheumatology (ACR) clinical criteria for knee OA and had symptomatic OA of at least 1 knee (index knee), with a Kellgren / Lawrence (K/L) score ≥ 1 in that knee

Exclusion Criteria

* Any patient with a history of trauma to the knee

* Any other form of arthritis (e.g., rheumatoid arthritis, seronegative spondyloarthropathies, gout, pyrophosphate disease, or other crystal arthropathy)
Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sohag University

OTHER

Sponsor Role lead

Responsible Party

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Amany Mohamed Abdelrahman

Physical Medicine, Rheumatology and Rehabilitation Department

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dalia Shaker Elgendy, MD

Role: STUDY_CHAIR

Sohag University

Hanan Sayed Abo-zaid, MD

Role: STUDY_DIRECTOR

Sohag University

Locations

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Sohag Faculty of Medicine

Sohag, , Egypt

Site Status RECRUITING

Countries

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Egypt

Central Contacts

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Amany Mohamed abdelrahman, master

Role: CONTACT

01066706352

Hanan Sayed Abo-zaid, MD

Role: CONTACT

01150532194

References

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Englund, M. (202+3). Osteoarthritis, part of life or a curable disease? A bird's-eye view. In Journal of Internal Medicine. John Wiley and Sons Inc. https://doi.org/10.1111/joim.13634 Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., Spertus, J. A., & Costa, F. (2005). Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute scientific statement. In Circulation (Vol. 112, Issue 17, pp. 2735-2752). https://doi.org/10.1161/CIRCULATIONAHA.105.169404 KELLGREN, J. H., & LAWRENCE, J. S. (1957). Radiological assessment of osteo-arthrosis. Annals of the Rheumatic Diseases, 16(4), 494-502. https://doi.org/10

Reference Type BACKGROUND

Krasnokutsky S, Oshinsky C, Attur M, Ma S, Zhou H, Zheng F, Chen M, Patel J, Samuels J, Pike VC, Regatte R, Bencardino J, Rybak L, Abramson S, Pillinger MH. Serum Urate Levels Predict Joint Space Narrowing in Non-Gout Patients With Medial Knee Osteoarthritis. Arthritis Rheumatol. 2017 Jun;69(6):1213-1220. doi: 10.1002/art.40069. Epub 2017 Apr 28.

Reference Type BACKGROUND
PMID: 28217895 (View on PubMed)

Related Links

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Other Identifiers

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Soh-Med-23-07-17MS

Identifier Type: -

Identifier Source: org_study_id

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