[Tc-99m]-RPI-087 as an Imaging Marker in Osteoarthritis of the Knee Compared to Healthy Volunteers

NCT ID: NCT03503825

Last Updated: 2019-01-15

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE1
• Total Enrollment: 24 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2018-08-16
• Study Completion Date: 2019-06-30

Brief Summary

The main purpose of this study is to test the safety and tolerability of T-087. The study will enroll 6 healthy volunteers (HVs) and 6-18 subjects with KOA. All eligible subjects will receive an intravenous injection of the radioactive investigational product (ip) (T-087), followed by SPECT/CT imaging of the knees and blood tests and clinical assessments for safety monitoring. Healthy volunteers will also have their whole body imaged and have extra blood drawn to determine where T-087 goes in the body. These additional procedures will be done on the same day as the ip administration, and repeated the following day. All subjects will have a final follow-up phone call within 2- 3 business days following the ip administration.

Detailed Description

This is a Phase 1, non-randomized, open label, single centre clinical trial. 6 healthy volunteers (3 male and 3 female,4 study visits) and 6-18 subjects with Osteoarthritis of the knee (3 study visits) will be enrolled. At visit 2, all subjects will have knee pain assessed, using a visual analogue scale, prior to receiving a single, 555 MBq (15 mCi)+/-10% dose of [Tc-99m)-RPI-T-087 injection. Knees will be imaged with a SPECT/CT camera at specified time-points post injection. Safety monitoring will include vital signs, ECG, clinical laboratory tests (serum biochemistry, haematology, urinalysis) and adverse event monitoring.

Additionally, HVs will have whole body planar imaging and blood sampling conducted at Visit 2 and 3 to evaluate bio-distribution, estimate dosimetry and measure clearance of total activity over time in blood samples. A final follow-up visit will be conducted by phone interview.

Once 6 HVs and 6 KOA participants have completed the study, a blinded assessment of the image data will be conducted to determine whether any more KOA subjects should be imaged.

Conditions

Healthy; Osteo Arthritis Knee

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Healthy Volunteers

Healthy volunteers will be administered \[Tc-99m\]-RPI-T-087 Injection, single IV dose of 555 MBq and will be monitored for safety, knee image evaluation, and radioactivity biodistribution and dosimetry.

Group Type: EXPERIMENTAL

[Tc-99m]-RPI-T-087 Injection

Intervention Type: DRUG

A single intravenous injection of \[Tc-99m\]-RPI-T-087 followed by SPECT/CT imaging of the knee (all subjects) and whole body planar imaging (Healthy volunteers only)

Osteo Arthritis of the knee

Subjects with knee osteoarthritis will be administered \[Tc-99m\]-RPI-T-087 Injection, single IV dose of 555 MBq and will be monitored for safety and knee image evaluation.

Group Type: EXPERIMENTAL

[Tc-99m]-RPI-T-087 Injection

Intervention Type: DRUG

A single intravenous injection of \[Tc-99m\]-RPI-T-087 followed by SPECT/CT imaging of the knee (all subjects) and whole body planar imaging (Healthy volunteers only)

Interventions

[Tc-99m]-RPI-T-087 Injection

A single intravenous injection of \[Tc-99m\]-RPI-T-087 followed by SPECT/CT imaging of the knee (all subjects) and whole body planar imaging (Healthy volunteers only)

Intervention Type: DRUG

Other Intervention Names

T-087

Eligibility Criteria

Inclusion Criteria

• All subjects must be able to read and speak in English and capable of giving signed informed consent.
• Female subjects must either, not be of reproductive potential, or not be pregnant and be willing to comply with appropriate family planning methods as specified in the protocol.
• Male subjects must either, not be of reproductive potential or be willing to comply with appropriate family planning methods as specified in the protocol.

Subjects with Knee Osteoarthritis (KOA)

• Age ≥ 40 to ≤ 70 years, at the time of signing the informed consent
• Have chronic pain due to OA of at least one knee identifiable as the target knee as their primary pain condition and some degree of pain every day from this condition.

For Healthy Volunteers:

• Age ≥ 18 to ≤ 35 years, at the time of signing the informed consent.
• No history of knee pain or known knee pathology confirmed by knee radiographs, obtained within the last year.

Exclusion Criteria

• Chronic pain conditions other than OA of the knee (KOA) as their predominant pain condition
• Cannot or will not agree to stop: all topical, oral and parenteral non-steroidal anti-inflammatory drugs (NSAIDs) for at least 48 hours before administration of the IP; stop turmeric and curcumin (supplements and dietary sources) for at least 48 hours before administration of the IP; avoid all exercise from at least 24 hours before administration of the IP up to the end of the last applicable imaging session.
• Systemic (including inhaled) and oral corticosteroid use currently or within 6 weeks prior to Visit 1.
• Surgical interventions of either knee or any other major surgery within the previous 6 months.
• Receipt of intra-articular corticosteroid injections within the previous 6 weeks prior to Visit 1 in the target knee or within the previous 2 weeks prior to Visit 1 in any other joint.
• Use of any other investigational medication or devices within 30 days prior to Visit 1.
• Orthopedic or prosthetic appliance in either knee which may confound scan interpretation.
• Screening ECG or laboratory assessments showing clinically significant abnormalities
• Refusal or inability to tolerate the scanning procedures
• Allergies to or cannot tolerate NSAIDs, the investigational product or sulfa drugs
• History of bleeding disorders or history of documented gastrointestinal ulcer disease.
• Received significant ionizing radiation exposure, in the last 12 months or undergoing occupational monitoring for radiation exposure.
• Allergies or sensitivity to any component of the investigational product. Subjects taking disulfiram (Antabuse) should be excluded from this study.
• History of alcohol or substance abuse
• Any medical condition or disease that in the opinion of the investigator makes the subject unsuitable to participate in this study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Reiley Pharmaceuticals Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Karen Gulenchyn, MD

Role: PRINCIPAL_INVESTIGATOR

St. Joseph's Hospital Hamilton

Locations

St. Joseph's Healthcare Hamilton

Hamilton, Ontario, Canada

Site Status: RECRUITING

Countries

Canada

Central Contacts

Janet Crouch, BScc, MRT(N)

Role: CONTACT

jcrouch@stjoes.ca

(905) 522-1155 ext. 35019

MaryLou Lawlor, RN

Role: CONTACT

mlawlor@stjosham.on.ca

(905) 522-1155 ext. 33790

Facility Contacts

Janet Crouch, RTNM

Role: primary

(905) 522-1155 ext. 35019

MaryLou, RN

Role: backup

(905) 522-1155 ext. 33790

Other Identifiers

RPI-T-087-001

Identifier Type: -

Identifier Source: org_study_id