Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
85 participants
INTERVENTIONAL
2022-03-01
2022-08-19
Brief Summary
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Detailed Description
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Aim of the clinical study: to determine the KOA grade through X-Ray studies, to perform nuclear magnetic resonance (NRM) analysis to assess the KOA severity. Data corroboration of the KOA degree with the results of the blood samples analysis, looking for the influence of the metabolic syndrome (MetS) parameters - high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides, glycemia, and then the body mass index (BMI). In the meantime, there is intended to associate the environment of origin of the patients from the trial group with the KOA incidence and severity. To determine the level of significant parameters in the synovial liquid extracted from the patients presenting KOA, analysis of the degradation products present in the synovial fluid of patients with KOA, such as free radicals, like reactive oxygen species (ROS) and reactive nitrogen species (RNS) and their influence on the severity of the pathology.
Conditions
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Study Design
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NON_RANDOMIZED
CROSSOVER
PREVENTION
NONE
Study Groups
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Patients without knee osteoarthritis (KOA) grade 0
Patient without knee affection
Influence of the metabolic syndrome (MetS) parameters on knee osteoarthritis (KOA) severity, the assesment of the reactive oxygen species and reactive nitrogen species in knee synovial fluid
Highlighting the influence of environment of origin on KOA incidence and corelated impact of high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides and body mass index (BMI). The analytes from synovial fluid were determined by fluorometric method.
The influence of patellofemoral morphology in the radiological severity of knee osteoarthritis
Highlighting the influence of distal femoral torsion angle, patellofemoral congruence angle and sulcus angle, in KOA severity under the influence of sex and age.
The influence of ROS from the synovial fluid on the severity of KOA
Highlighting the influence of ROS from the synovial fluid in KOA severity under the influence of some biochemicals blood constants.
Patients with KOA grade I
Kellgren-Lawrence classification (KL) grade I- doubtful narrowing of the joint space and possible osteophytes
Influence of the metabolic syndrome (MetS) parameters on knee osteoarthritis (KOA) severity, the assesment of the reactive oxygen species and reactive nitrogen species in knee synovial fluid
Highlighting the influence of environment of origin on KOA incidence and corelated impact of high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides and body mass index (BMI). The analytes from synovial fluid were determined by fluorometric method.
The influence of patellofemoral morphology in the radiological severity of knee osteoarthritis
Highlighting the influence of distal femoral torsion angle, patellofemoral congruence angle and sulcus angle, in KOA severity under the influence of sex and age.
The influence of ROS from the synovial fluid on the severity of KOA
Highlighting the influence of ROS from the synovial fluid in KOA severity under the influence of some biochemicals blood constants.
Patients with KOA grade II
KL grade II - definite osteophytes and possible narrowing of joint space.
Influence of the metabolic syndrome (MetS) parameters on knee osteoarthritis (KOA) severity, the assesment of the reactive oxygen species and reactive nitrogen species in knee synovial fluid
Highlighting the influence of environment of origin on KOA incidence and corelated impact of high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides and body mass index (BMI). The analytes from synovial fluid were determined by fluorometric method.
The influence of patellofemoral morphology in the radiological severity of knee osteoarthritis
Highlighting the influence of distal femoral torsion angle, patellofemoral congruence angle and sulcus angle, in KOA severity under the influence of sex and age.
The influence of ROS from the synovial fluid on the severity of KOA
Highlighting the influence of ROS from the synovial fluid in KOA severity under the influence of some biochemicals blood constants.
Patients with KOA grade III
KL grade III- definite narrowing of the joint space, significant osteophytosis, and possible bone deformities.
Influence of the metabolic syndrome (MetS) parameters on knee osteoarthritis (KOA) severity, the assesment of the reactive oxygen species and reactive nitrogen species in knee synovial fluid
Highlighting the influence of environment of origin on KOA incidence and corelated impact of high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides and body mass index (BMI). The analytes from synovial fluid were determined by fluorometric method.
The influence of patellofemoral morphology in the radiological severity of knee osteoarthritis
Highlighting the influence of distal femoral torsion angle, patellofemoral congruence angle and sulcus angle, in KOA severity under the influence of sex and age.
The influence of ROS from the synovial fluid on the severity of KOA
Highlighting the influence of ROS from the synovial fluid in KOA severity under the influence of some biochemicals blood constants.
Patients with KOA grade IV
KL grade IV- marked joint space narrowing accompanied by deformities, bone sclerosis, and large osteophytes
Influence of the metabolic syndrome (MetS) parameters on knee osteoarthritis (KOA) severity, the assesment of the reactive oxygen species and reactive nitrogen species in knee synovial fluid
Highlighting the influence of environment of origin on KOA incidence and corelated impact of high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides and body mass index (BMI). The analytes from synovial fluid were determined by fluorometric method.
The influence of patellofemoral morphology in the radiological severity of knee osteoarthritis
Highlighting the influence of distal femoral torsion angle, patellofemoral congruence angle and sulcus angle, in KOA severity under the influence of sex and age.
The influence of ROS from the synovial fluid on the severity of KOA
Highlighting the influence of ROS from the synovial fluid in KOA severity under the influence of some biochemicals blood constants.
Interventions
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Influence of the metabolic syndrome (MetS) parameters on knee osteoarthritis (KOA) severity, the assesment of the reactive oxygen species and reactive nitrogen species in knee synovial fluid
Highlighting the influence of environment of origin on KOA incidence and corelated impact of high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides and body mass index (BMI). The analytes from synovial fluid were determined by fluorometric method.
The influence of patellofemoral morphology in the radiological severity of knee osteoarthritis
Highlighting the influence of distal femoral torsion angle, patellofemoral congruence angle and sulcus angle, in KOA severity under the influence of sex and age.
The influence of ROS from the synovial fluid on the severity of KOA
Highlighting the influence of ROS from the synovial fluid in KOA severity under the influence of some biochemicals blood constants.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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Iacob Czihac Emergency Military Clinical Hospital
NETWORK
Responsible Party
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Principal Investigators
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Nicoleta B Tudorachi, MD
Role: PRINCIPAL_INVESTIGATOR
"Ovidius" University of Constanța, Romania
Locations
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3 "Iacob Czihac" Emergency Military Clinical Hospital, 7-9 General Henri Mathias Berthelot St., 700483 Iasi, Romania
Iași, , Romania
Countries
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Other Identifiers
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10/A575
Identifier Type: -
Identifier Source: org_study_id
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