A Study of the Safety and Efficacy of ONO-4641 in Patients With Relapsing-Remitting Multiple Sclerosis

NCT ID: NCT01081782

Last Updated: 2013-12-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

407 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-03-31

Study Completion Date

2011-12-31

Brief Summary

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The objective of this study is to evaluate the safety and efficacy of ONO-4641 in patients with relapsing-remitting multiple sclerosis over a 26-week treatment period.

Detailed Description

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Conditions

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Multiple Sclerosis

Keywords

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Multiple Sclerosis ONO-4641

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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E1

Group Type EXPERIMENTAL

ONO-4641

Intervention Type DRUG

0.15 mg once per day for 26 weeks

E2

Group Type EXPERIMENTAL

ONO-4641

Intervention Type DRUG

0.1 mg once per day for 26 weeks

E3

Group Type EXPERIMENTAL

ONO-4641

Intervention Type DRUG

0.05 mg once per day for 26 weeks

P

Group Type PLACEBO_COMPARATOR

ONO-4641 placebo

Intervention Type DRUG

Placebo once per day for 26 weeks

Interventions

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ONO-4641

0.15 mg once per day for 26 weeks

Intervention Type DRUG

ONO-4641

0.1 mg once per day for 26 weeks

Intervention Type DRUG

ONO-4641

0.05 mg once per day for 26 weeks

Intervention Type DRUG

ONO-4641 placebo

Placebo once per day for 26 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Adult male or female aged 18-55 years inclusive at screening
* Patients who have a definite diagnosis of relapsing-remitting Multiple Sclerosis

Exclusion Criteria

* Multiple Sclerosis course other than relapsing-remitting multiple sclerosis
* History of malignancy
* History of clinically significant chronic disease of the immune system (other than Multiple Sclerosis)
* Inability to undergo Gd-enhanced MRI scans
* Diagnosis of diabetes mellitus (type I or type II)
Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ono Pharma USA Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ono Pharma USA, Inc.

Role: STUDY_DIRECTOR

Ono Pharmaceutical Co. Ltd

Locations

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Tucson Clinical Site 133

Tucson, Arizona, United States

Site Status

Aurora Clinical Site 132

Aurora, Colorado, United States

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Fort Collins Clinical Site 123

Fort Collins, Colorado, United States

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Fairfield Clinical Site 110

Fairfield, Connecticut, United States

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Ormond Beach Clinical Site 129

Ormond Beach, Florida, United States

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Sarasota Clinical Site 116

Sarasota, Florida, United States

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Sarasota Clinical Site 117

Sarasota, Florida, United States

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Northbrook Clinical Site 135

Northbrook, Illinois, United States

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Fort Wayne Clinical Site 111

Fort Wayne, Indiana, United States

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Indianapolis Clinical Site 121

Indianapolis, Indiana, United States

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Detroit Clinical Site 104

Detroit, Michigan, United States

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Farmington Hills Clinical Site 126

Farmington Hills, Michigan, United States

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Lebanon Clinical Site 115

Lebanon, New Hampshire, United States

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Albuquerque Clinical Site 106

Albuquerque, New Mexico, United States

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Rochester Clinical Site 108

Rochester, New York, United States

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Charlotte Clinical Site 125

Charlotte, North Carolina, United States

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HighPoint Clinical Site 128

HighPoint, North Carolina, United States

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Raleigh Clinical Site 103

Raleigh, North Carolina, United States

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Akron Clinical Site 112

Akron, Ohio, United States

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Philadelphia Clinical Site 120

Philadelphia, Pennsylvania, United States

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Knoxville Clinical Site 134

Knoxville, Tennessee, United States

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Round Rock Clinical Site 107

Round Rock, Texas, United States

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Seattle Clinical Site 118

Seattle, Washington, United States

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Brugge Clinical Site 203

Bruges, , Belgium

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La Louviere Clinical Site 201

La Louvière, , Belgium

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Sijsele Clinical Site 202

Sijsele, , Belgium

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Gatineau Clinical Site 114

Gatineau, Quebec, Canada

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Greenfield Park Clinical Site 109

Greenfield Park, Quebec, Canada

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Vancouver Clinical Site 131

British Columbia, , Canada

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Montreal Clinical Site 113

Québec, , Canada

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Montreal Clinical Site 102

Québec, , Canada

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Olomouc Clinical Site 212

Olomouc, , Czechia

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Ostrava Clinical Site 214

Ostrava, , Czechia

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Pardubice Clinical Site 211

Pardubice, , Czechia

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Praha 5 Clinical Site 213

Prague, , Czechia

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Berlin Clinical Site 223

Berlin, , Germany

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Essen Clinical Site 222

Essen, , Germany

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Giessen Clinical Site 221

Giessen, , Germany

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Leipzig Clinical Site 229

Leipzig, , Germany

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Mainz Clinical Site 231

Mainz, , Germany

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Marburg Clinical Site 228

Marburg, , Germany

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Munster Clinical Site 225

Münster, , Germany

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Tubingen Clinical Site 226

Tübingen, , Germany

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Ulm Clinical Site 230

Ulm, , Germany

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Athens Clinical Site 243

Athens, , Greece

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Thessaloniki Clinical Site 245

Thessaloniki, , Greece

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Kanto Region Clinical Site 404

Kanto, , Japan

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Kanto Region Clinical Site 405

Kanto, , Japan

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Kanto Region Clinical Site 406

Kanto, , Japan

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Kanto Region Clinical Site 409

Kanto, , Japan

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Kinki Region Clinical Site 401

Kinki, , Japan

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Kinki Region Clinical Site 407

Kinki, , Japan

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Kinki Region Clinical Site 408

Kinki, , Japan

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Tohoku Region Clinical Site 403

Tōhoku, , Japan

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Tohoku Region Clinical Site 410

Tōhoku, , Japan

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Bialystok Clinical Site 305

Bialystok, , Poland

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Czeladz Clinical Site 303

Czeladź, , Poland

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Gdansk Clinical Site 302

Gdansk, , Poland

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Katowice Clinical Site 309

Katowice, , Poland

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Krakow Clinical Site 307

Krakow, , Poland

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Lodz Clinical Site 306

Lodz, , Poland

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Plewiska Clinical Site 304

Plewiska, , Poland

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Warszawa Clinical Site 308

Warsaw, , Poland

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Chelyabinsk Clinical Site 322

Chelyabinsk, , Russia

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Kaluga Clinical Site 328

Kaluga, , Russia

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Kazan Clinical Site 333

Kazan', , Russia

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Moscow Clinical Site 332

Moscow, , Russia

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Nizhniy Novgorod Clinical Site 321

Nizhny Novgorod, , Russia

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Novosibirsk Clinical Site 324

Novosibirsk, , Russia

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St. Petersburg Clinical Site 325

Saint Petersburg, , Russia

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St. Petersburg Clinical Site 327

Saint Petersburg, , Russia

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Samara Clinical Site 328

Samara, , Russia

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Ufa Clinical Site 326

Ufa, , Russia

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Yaroslavl Clinical Site 331

Yaroslavl, , Russia

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Barcelona Clinical Site 252

Barcelona, , Spain

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Barcelona Clinical Site 253

Barcelona, , Spain

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Bilbao Clinical Site 255

Bilbao, , Spain

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Girona Clinical Site 254

Girona, , Spain

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Hospitalet de Llobregat Clinical Site 251

L'Hospitalet de Llobregat, , Spain

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Sevilla Clinical Site 256

Seville, , Spain

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Dnipropetrovsk Clinical Site 341

Dnipropetrovsk, , Ukraine

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Donetsk Clinical Site 345

Donetsk, , Ukraine

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Kharkiv Clinical Site 346

Kharkiv, , Ukraine

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Kyiv Clinical Site 344

Kyiv, , Ukraine

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Lviv Clinical Site 343

Lviv, , Ukraine

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Vinnytsya Clinical Site 342

Vinnytsia, , Ukraine

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Countries

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United States Belgium Canada Czechia Germany Greece Japan Poland Russia Spain Ukraine

Other Identifiers

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ONO-4641POU006

Identifier Type: -

Identifier Source: org_study_id