Effect of Magnesium Sulphate on Coagulation

NCT ID: NCT01032213

Last Updated: 2013-08-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-01-31

Study Completion Date

2010-10-31

Brief Summary

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Arterial and venous thrombotic events are the clinical manifestation of postoperative hypercoagulability. Altered serum magnesium may play a role in the balance of coagulation. In this study, the investigators investigated the effect of magnesium sulphate on the postoperative coagulation change in total intravenous anesthesia (TIVA).

Detailed Description

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Conditions

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Myoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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group C

control group

Group Type PLACEBO_COMPARATOR

normal saline

Intervention Type DRUG

Group S received the same volume of isotonic saline as same method.

group M

magnesium group

Group Type EXPERIMENTAL

Magnesium Sulfate

Intervention Type DRUG

Group M received 50 mg/kg of magnesium sulphate on 100 ml of isotonic saline over 10 minutes during the anesthesia induction, followed by the 15 mg/kg/h by continuous infusion during the operation

Interventions

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Magnesium Sulfate

Group M received 50 mg/kg of magnesium sulphate on 100 ml of isotonic saline over 10 minutes during the anesthesia induction, followed by the 15 mg/kg/h by continuous infusion during the operation

Intervention Type DRUG

normal saline

Group S received the same volume of isotonic saline as same method.

Intervention Type DRUG

Other Intervention Names

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magnesium sulphate isotonic saline

Eligibility Criteria

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Inclusion Criteria

* ASA Ⅰ-Ⅱ patients undergoing pelviscopic gynecologic operation under general anesthesia.

Exclusion Criteria

* Pregnancy
* Previous known hematologic disorder
* Recent medication interfering with hemostasis
* Severe anemia
* Liver disease
* Cardiovascular or respiratory disease
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Seoul National University Bundang Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hyo-Seok Na

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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TEG/Mg

Identifier Type: -

Identifier Source: org_study_id