Mitochondrial Dysfunction in Trauma-related Coagulopathy
NCT ID: NCT05004844
Last Updated: 2021-09-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
40 participants
OBSERVATIONAL
2021-10-31
2023-01-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Viscoelastic assays and aggregometry tests
Viscoelastic assays and aggregometry tests performed with ROTEM will allow us to characterize the clot forming abilities and platelet functions of our patients. ROTEM is used routinely for aiding clinicians in choosing the appropriate blood products for patients ROTEM requires samples of whole blood in an amount that does not entail additional burden or risk for patients. In our study, viscoelastic assays and aggregometry will be performed upon arrival, and 24-,48-,72-hours post-admission.
Eligibility Criteria
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Inclusion Criteria
* Injury Severity Score (ISS) 16 or greater,
* age of 18 years or greater,
* hemorrhage confirmed with extended focused assessment with sonography in trauma (eFAST) or computer tomography (CT)
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Petra Hartmann MD Ph.D.
OTHER
Responsible Party
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Petra Hartmann MD Ph.D.
Associate Professor
Principal Investigators
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Endre Prof. Dr. Varga, M.D,Ph.D,DSc
Role: STUDY_DIRECTOR
Department of Traumatology, University of Szeged
Petra Dr. Hartmann, M.D., Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Department of Traumatology, University of Szeged
Locations
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Department of Traumatology, University of Szeged
Szeged, , Hungary
Countries
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Central Contacts
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Facility Contacts
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References
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Moore EE, Moore HB, Kornblith LZ, Neal MD, Hoffman M, Mutch NJ, Schochl H, Hunt BJ, Sauaia A. Trauma-induced coagulopathy. Nat Rev Dis Primers. 2021 Apr 29;7(1):30. doi: 10.1038/s41572-021-00264-3.
Barile CJ, Herrmann PC, Tyvoll DA, Collman JP, Decreau RA, Bull BS. Inhibiting platelet-stimulated blood coagulation by inhibition of mitochondrial respiration. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2539-43. doi: 10.1073/pnas.1120645109. Epub 2012 Jan 30.
Kornblith LZ, Moore HB, Cohen MJ. Trauma-induced coagulopathy: The past, present, and future. J Thromb Haemost. 2019 Jun;17(6):852-862. doi: 10.1111/jth.14450. Epub 2019 May 13.
Kutcher ME, Redick BJ, McCreery RC, Crane IM, Greenberg MD, Cachola LM, Nelson MF, Cohen MJ. Characterization of platelet dysfunction after trauma. J Trauma Acute Care Surg. 2012 Jul;73(1):13-9. doi: 10.1097/TA.0b013e318256deab.
Javor P, Rarosi F, Horvath T, Torok L, Hartmann P. Mitochondrial Dysfunction in Trauma-Related Coagulopathy: Is There Causality? Study Protocol for a Prospective Observational Study. Eur Surg Res. 2023;64(2):304-309. doi: 10.1159/000521670. Epub 2021 Dec 24.
Other Identifiers
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5500/2021-SZTE
Identifier Type: -
Identifier Source: org_study_id
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