Non-invasive Measurement of Hemoglobin in Retinal Arteries

NCT ID: NCT01025011

Last Updated: 2009-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-03-31

Study Completion Date

2010-06-30

Brief Summary

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The purpose of this study is to test a new non-invasive tool to measure hemoglobin in retinal arteries.

Detailed Description

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To our knowledge no tool exists that allows for direct collection of hemoglobin data in the eye. In many eye diseases (especially diabetic and hypertensive retinopathy as well as in retinal vessel occlusions) retinal circulation is modified. Knowing hemoglobin concentration on the site of the pathology will give us further information about the pathogenesis of this diseases and may provide a new possibility in therapy.

The purpose of this study is to test a new non-invasive tool to measure hemoglobin in retinal arteries. Healthy volunteers from the eye clinic and pregnant otherwise healthy patients of the gynecological department of the Triemli Hospital, Zurich, as well as anemic gynecological patients that show up for a check-up are included.

Hemoglobin will be quantified by a blood draw of a cubital vein. Using a Fundus Camera (Nidek AFC-230) pictures of the fundus will be taken from each study patient. Afterwards the study investigator selects a retinal artery of interest which will be used for measuring the hemoglobin concentration. Intensity of the green channel of the camera chip is determined with the aid of the law of Lambert-Beer.

Absolute Hemoglobin concentration is calculated in relation to the vessel volume.

Conditions

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Healthy Subjects Anemia

Keywords

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retinal hemoglobin concentration non-invasive hemoglobin measurement

Study Groups

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healthy volunteers, anemic patients

healthy volunteers from the eye and gynecology department pregnant patients with anemia

Fundus photography, cubital blood draw

Intervention Type DEVICE

blood draw from a cubital vein to measure hemoglobin concentration taking a fundus photography with a Nidek AFC-230, no pupil dilation needed

Interventions

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Fundus photography, cubital blood draw

blood draw from a cubital vein to measure hemoglobin concentration taking a fundus photography with a Nidek AFC-230, no pupil dilation needed

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* healthy volunteers
* pregnant patients from the Triemli Hospital that came for a routine check up
* anemic patients of the same dept with various gynecological tumors

Exclusion Criteria

* any known retinal eye disease
* poor fundus picture quality due to fixtion problems or too small pupil or media intransparency
* not willing to participate in a study
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Triemli Hospital

OTHER

Sponsor Role lead

Responsible Party

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Stadtpital Triemli (Triemli Hospital)

Principal Investigators

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Yves Robert, Prof MD

Role: PRINCIPAL_INVESTIGATOR

Triemli Hospital

Locations

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Stadtpital Zürich, Triemli Hospital

Zurich, Canton of Zurich, Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Yves Robert, Prof MD

Role: CONTACT

Phone: +41 44 466

Email: [email protected]

Facility Contacts

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Yves Robert, Prof MD

Role: primary

Other Identifiers

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D20028132

Identifier Type: -

Identifier Source: org_study_id