Activation of Cervical and Upper Thoracic Brown Adipose Tissue in Humans Via Beta-adrenergic Stimulation
NCT ID: NCT01015794
Last Updated: 2013-02-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
25 participants
INTERVENTIONAL
2009-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
TRIPLE
Study Groups
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Adrenergic agonist
ephedrine hydrochloride
single oral dose, 1mg/kg body weight
ephedrine hydrochloride
single dose of 1 mg/kg body weight
Interventions
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ephedrine hydrochloride
single oral dose, 1mg/kg body weight
ephedrine hydrochloride
single dose of 1 mg/kg body weight
Eligibility Criteria
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Inclusion Criteria
* Free of overt coronary disease (on history, medical examination and ECG)
* Fasting plasma glucose \< 6.1 mmol/L and 2 hour OGTT glucose \< 7.8 mmol/L
* Unmedicated
* No major illness
* BMI 18 - 25
* Males aged 20 - 40 years
* Free of overt coronary disease (on history, medical examination and ECG)
* Unmedicated
* No major illness
* BMI 30+
* Weight \< 100 kg
* Height \< 185 cm
Exclusion Criteria
* Smokers
* Lactose intolerance
* Unable to give informed consent
* Smokers
* Lactose intolerance
* Participant in research projects involving ionising radiation within the past 5 years
* claustrophobia
20 Years
40 Years
MALE
Yes
Sponsors
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Bayside Health
OTHER_GOV
Responsible Party
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Locations
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Alfred Hospital Heart Centre
Prahran, Victoria, Australia
Countries
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References
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Carey AL, Formosa MF, Van Every B, Bertovic D, Eikelis N, Lambert GW, Kalff V, Duffy SJ, Cherk MH, Kingwell BA. Ephedrine activates brown adipose tissue in lean but not obese humans. Diabetologia. 2013 Jan;56(1):147-55. doi: 10.1007/s00125-012-2748-1. Epub 2012 Oct 13.
Other Identifiers
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404/09
Identifier Type: -
Identifier Source: org_study_id
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