Beta2-adrenergic Agonism and Muscle Remodelling

NCT ID: NCT03565302

Last Updated: 2020-03-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-06-25

Study Completion Date

2021-05-30

Brief Summary

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The study aims to investigate gender-specific adaptations to beta2-adrenoceptor stimulation with selective short- and long-acting beta2-agonist with emphasis on skeletal muscle in relation to performance enhancing effects and anti-doping

Detailed Description

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Conditions

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Hypertrophy Physiologic Hypertrophy Physical Activity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Control

Subjects receive placebo treatment

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type OTHER

Subjects are treated with placebo

Long acting beta2-agonist

Subjects are treated with long-acting beta2-agonist formoterol

Group Type EXPERIMENTAL

Formoterol

Intervention Type DRUG

Subjects are treated with daily inhalation of formoterol

Short acting beta2-agonist

Subjects are treated with short-acting beta2-agonist terbutaline

Group Type EXPERIMENTAL

Terbutaline

Intervention Type DRUG

Subjects are treated with daily inhalation of terbutaline

Interventions

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Formoterol

Subjects are treated with daily inhalation of formoterol

Intervention Type DRUG

Terbutaline

Subjects are treated with daily inhalation of terbutaline

Intervention Type DRUG

Placebo

Subjects are treated with placebo

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy men and women, aged 18-45 years
* VO2max \>55 ml/kg/min for men and \>50 ml/kg/min for women (± biologic and techinical variation of 5.6% (Katch et al. 1982)
* Body Mass Index (BMI) \< 26

Exclusion Criteria

* Chronic user of beta2-agonist or allergy towards study drugs
* Serious adverse side effects of the used study drug
* Chronic disease that by the project physician would affect any of the outcomes of the study
* Smoker
* Chronic use of prescription medication (other than contraceptives for women)
* Pregnancy
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Morten Hostrup, PhD

OTHER

Sponsor Role lead

Responsible Party

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Morten Hostrup, PhD

Associate Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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August Krogh Building

Copenhagen, , Denmark

Site Status RECRUITING

Countries

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Denmark

Facility Contacts

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Morten Hostrup, PhD

Role: primary

+4524474785

Other Identifiers

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FOR/TER

Identifier Type: -

Identifier Source: org_study_id

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