cAMP Signaling and Muscle Adaptations

NCT ID: NCT02557581

Last Updated: 2017-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

72 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-07-31

Study Completion Date

2017-10-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The role of cAMP signaling mediated by beta2-adrenergic stimulation with agonists has been well-studied in skeletal muscles of animals. Studies in humans are scant and the scope of the present study is thus to investigate the role of cAMP signaling by beta2-adrenergic stimulation for muscle adaptations in humans.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Muscle Hypertrophy in Healthy Young Men

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Terbutaline

Beta2-adrenergic stimulation with terbutaline

Group Type EXPERIMENTAL

No training

Intervention Type OTHER

Endurance training

Intervention Type OTHER

Resistance Training

Intervention Type OTHER

Terbutaline

Intervention Type DRUG

Placebo

Placebo

Group Type PLACEBO_COMPARATOR

No training

Intervention Type OTHER

Endurance training

Intervention Type OTHER

Resistance Training

Intervention Type OTHER

Placebo

Intervention Type DRUG

Clenbuterol

Beta2-adrenergic stimulation with clenbuterol

Group Type EXPERIMENTAL

No training

Intervention Type OTHER

Clenbuterol

Intervention Type DRUG

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

No training

Intervention Type OTHER

Endurance training

Intervention Type OTHER

Resistance Training

Intervention Type OTHER

Terbutaline

Intervention Type DRUG

Clenbuterol

Intervention Type DRUG

Placebo

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* healthy young men
* 18-35 years of age
* Informed consent
* Active 2-5 hours of training pr. week
* Maximal oxygen uptake (ml/min/kg) of 40-60
* Lean body mass of 55-65 kg / Lean mass index 14-22 kg/m2

Exclusion Criteria

* Smoker
* Allergy towards study drugs
* Chronic disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Morten Nielsen

Post.Doc

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Department of Nutrition, Exercise and Sports

Copenhagen, , Denmark

Site Status RECRUITING

Bispebjerg University Hospital

Copenhagen, , Denmark

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Denmark

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Morten Hostrup, PhD

Role: CONTACT

Phone: +4524474785

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Morten Hostrup, PhD

Role: primary

Morten Hostrup, PhD

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

TUD

Identifier Type: -

Identifier Source: org_study_id