Lipid Profile in Patients With Severe Sepsis or Septic Shock Under Strict or Liberal Glycemic Control
NCT ID: NCT01013662
Last Updated: 2011-08-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
69 participants
INTERVENTIONAL
2005-01-31
2007-07-31
Brief Summary
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Hypothesis: establish a relationship between lipid metabolism alterations and glycemic control or infusion of exogenous insulin
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Detailed Description
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One group called intensive glycemic control with glycemic levels been between 80 to 110 mg/dl with exogenous insulin.
The other group called conventional glycemic control with glycemic levels been between 180 and 220 mg/dl.
Blood samples were collected at 0, 12, 24, 48 and 72 hours to measure HDL, LDL, Total cholesterol, free fatty acids and oxidized LDL.
Clinical data as creatinine, P/F ratio, bilirubins, platelets, lactate, arterial blood gasometry were either monitored.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SCREENING
NONE
Study Groups
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glycemic control between 180 and 220 mg/dl
glycemic control
exogenous insulin
glycemic control for levels between 80 and 110 mg/dl
glycemic control
exogenous insulin
Interventions
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glycemic control
exogenous insulin
Eligibility Criteria
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Inclusion Criteria
* with the diagnostic of septic shock or severe sepsis
Exclusion Criteria
* previous diagnosis of any cancer,
* diagnosis of leptospirosis,
* diagnosis of aids.
18 Years
80 Years
ALL
No
Sponsors
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University of Sao Paulo
OTHER
Responsible Party
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Universidade de Sao Paulo
References
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Cappi SB, Noritomi DT, Velasco IT, Curi R, Loureiro TC, Soriano FG. Dyslipidemia: a prospective controlled randomized trial of intensive glycemic control in sepsis. Intensive Care Med. 2012 Apr;38(4):634-41. doi: 10.1007/s00134-011-2458-z. Epub 2012 Feb 2.
Other Identifiers
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scap1501
Identifier Type: -
Identifier Source: org_study_id
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