Investigating the Accuracy of the Home Glucose Monitors in Hypoglycemia

NCT ID: NCT01013402

Last Updated: 2009-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

51 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-12-31

Study Completion Date

2009-08-31

Brief Summary

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The purpose of this study is to compare the accuracies and the capillary and venous comparabilities of five different home glucose monitors; Optium Xceed, Contour Ts, Accu-chek Go, One Touch Select and Ez Smart in an adult population.

Detailed Description

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Conditions

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Hypoglycemia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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volunteers for insulin hypoglycemia test

None of the subjects had diabetes mellitus or any other metabolic diseases. They were not taking any medicine and they did not have anemia or polycythemia. Also none of the patients had any condition causing hypoxia or any compromise in peripheral circulation.

Group Type EXPERIMENTAL

Human insulin

Intervention Type DRUG

The test was performed in the morning after an overnight fasting and the patients remained supine during the procedure. Two intravenous lines in both arms were established before the procedure. Venous blood was obtained for serum glucose before regular insulin (0.1 U/kg ) is injected and 30 and 45 minutes thereafter. If adequate hypoglycemia was not achieved at this period, a second dose of regular insulin (0.05U/kg) was injected intravenously. In subjects who had not reached the aimed hypoglycemia levels, the test was performed in another day with a higher initial insulin dosage (0.2U/kg).

Human Insulin

Intervention Type DRUG

0.1U/kg IV pulse.

Interventions

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Human insulin

The test was performed in the morning after an overnight fasting and the patients remained supine during the procedure. Two intravenous lines in both arms were established before the procedure. Venous blood was obtained for serum glucose before regular insulin (0.1 U/kg ) is injected and 30 and 45 minutes thereafter. If adequate hypoglycemia was not achieved at this period, a second dose of regular insulin (0.05U/kg) was injected intravenously. In subjects who had not reached the aimed hypoglycemia levels, the test was performed in another day with a higher initial insulin dosage (0.2U/kg).

Intervention Type DRUG

Human Insulin

0.1U/kg IV pulse.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Being under investigation for pituitary- adrenal functions

Exclusion Criteria

* Diabetes mellitus or any other chronic metabolic disease
* Taking medicine for any reason
* Anemia
* Polyctemia
* Compromised circulation
* Hypoxia
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Gulhane School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Gulhane School of Medicine Department of Endocrinology and Metabolism

Locations

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Gulhane School of Medicine Department of Endocrinology and Metabolism

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Trajanoski Z, Brunner GA, Gfrerer RJ, Wach P, Pieber TR. Accuracy of home blood glucose meters during hypoglycemia. Diabetes Care. 1996 Dec;19(12):1412-5. doi: 10.2337/diacare.19.12.1412.

Reference Type BACKGROUND
PMID: 8941473 (View on PubMed)

Funk DL, Chan L, Lutz N, Verdile VP. Comparison of capillary and venous glucose measurements in healthy volunteers. Prehosp Emerg Care. 2001 Jul-Sep;5(3):275-7. doi: 10.1080/10903120190939788.

Reference Type BACKGROUND
PMID: 11446542 (View on PubMed)

Clinical and Laboratory Standards Institute: Point-of-Care Glucose Testing in Acute and Chronic Care Facilities: Approved Guideline, 2nd ed. CLSI Document C30-A2. Wayne,PA: Clinical and Laboratory Standards Institute, 2002

Reference Type BACKGROUND

Clarke WL, Cox D, Gonder-Frederick LA, Carter W, Pohl SL. Evaluating clinical accuracy of systems for self-monitoring of blood glucose. Diabetes Care. 1987 Sep-Oct;10(5):622-8. doi: 10.2337/diacare.10.5.622.

Reference Type BACKGROUND
PMID: 3677983 (View on PubMed)

Other Identifiers

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GSM-012009

Identifier Type: -

Identifier Source: org_study_id

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