Telepharmacy Robotic Medicine Delivery Unit "TRMDU" Assessment

NCT ID: NCT01007006

Last Updated: 2019-07-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2010-12-31

Study Completion Date

2011-12-31

Brief Summary

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The objective of this study is to evaluate whether use of TRMDU in addition to medication review leads to improved outcomes and reduced health care costs for patients when compared with medication review alone. The study will be conducted in patients assigned to Department of Defense (DOD) Warrior Transition Units (WTU's), similar DOD units, and VA polytrauma centers.

Detailed Description

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The military has been witnessing an increased number of patients with combat related impairments such as traumatic brain injury, post traumatic stress disorder and polytrauma which has lead to sub optimal medication self management. TRMDU is a medical device developed by INRange Systems Inc. that delivers medications and emits a sound alert to assist the patient. It can be used in a hospital, clinic, or residential setting. It can be remotely accessed by the health care professionals, and it allows physicians and other prescribers to remotely change scheduling or adjust prescriptions.

Use of TRMDU in hospital settings is expected to improve outcomes by improving medication self management, increasing adherence, reducing medication errors, and thereby associated costs. Further, it may contribute to overall improvement in a patient's psychological well-being and quality of life.

Conditions

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Traumatic Brain Injury Posttraumatic Stress Disorders Trauma Combat Disorders Pain

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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TMRDU

Telepharmacy Robotic Medicine Delivery Unit (TMRDU) group will receive TMRDU plus medication management

Group Type EXPERIMENTAL

TMRDU

Intervention Type DEVICE

The TMRDU will assist study subjects with taking their medications as prescribed by notifying them when the next dose is due and tracking whether and when it was taken.

Control

Control arm will receive only medication management, no TMRDU.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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TMRDU

The TMRDU will assist study subjects with taking their medications as prescribed by notifying them when the next dose is due and tracking whether and when it was taken.

Intervention Type DEVICE

Other Intervention Names

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Electronic Medication Management Assistant, (EMMA) (R)

Eligibility Criteria

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Inclusion Criteria

* At least 18 years of age
* Alert and oriented to person , place and time
* Primarily use English language for written and oral communication
* Have diagnosis of Traumatic Brain Injury(TBI) Multiple Traumatic Brain Injury (MTBI), Post Traumatic Stress Disorder (PTSD) or Polytrauma.
* Taking at least 4 chronic prescription medications
* Living in a participating WTU or enrolled in Tampa Veterans Administration polytrauma outpatient treatment facility at the time of enrollment
* Achieve a minimum score of 24 on Mini-Mental State Examination

Exclusion Criteria

* Disabilities preventing safe use of the TRMDU
* Projected life expectancy of less than 3 months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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U.S. Army Medical Research and Development Command

FED

Sponsor Role collaborator

University of Illinois at Chicago

OTHER

Sponsor Role lead

Responsible Party

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Daniel R. Touchette

Professor of Pharmacy

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Daniel R Touchette, MA

Role: PRINCIPAL_INVESTIGATOR

University of Illinois at Chicago

Jill M Winters, PhD

Role: PRINCIPAL_INVESTIGATOR

Columbia College of Nursing

Locations

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Naval Hospital Camp Pendleton

Camp Pendleton, California, United States

Site Status

James A Haley VA Hospital and Polytrauma Facility

Tampa, Florida, United States

Site Status

Ireland Army Community Hospital

Fort Knox, Kentucky, United States

Site Status

Countries

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United States

References

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Bates DW. Preventing medication errors: a summary. Am J Health Syst Pharm. 2007 Jul 15;64(14 Suppl 9):S3-9; quiz S24-6. doi: 10.2146/ajhp070190.

Reference Type BACKGROUND
PMID: 17617512 (View on PubMed)

Cantor JB, Ashman T, Gordon W, Ginsberg A, Engmann C, Egan M, Spielman L, Dijkers M, Flanagan S. Fatigue after traumatic brain injury and its impact on participation and quality of life. J Head Trauma Rehabil. 2008 Jan-Feb;23(1):41-51. doi: 10.1097/01.HTR.0000308720.70288.af.

Reference Type BACKGROUND
PMID: 18219234 (View on PubMed)

Ernst FR, Grizzle AJ. Drug-related morbidity and mortality: updating the cost-of-illness model. J Am Pharm Assoc (Wash). 2001 Mar-Apr;41(2):192-9. doi: 10.1016/s1086-5802(16)31229-3.

Reference Type BACKGROUND
PMID: 11297331 (View on PubMed)

Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189-98. doi: 10.1016/0022-3956(75)90026-6. No abstract available.

Reference Type BACKGROUND
PMID: 1202204 (View on PubMed)

Hoge CW, Castro CA, Messer SC, McGurk D, Cotting DI, Koffman RL. Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care. N Engl J Med. 2004 Jul 1;351(1):13-22. doi: 10.1056/NEJMoa040603.

Reference Type BACKGROUND
PMID: 15229303 (View on PubMed)

Institute for Healthcare Improvement. (2009). Prevent adverse drug events (medication reconciliation).

Reference Type BACKGROUND

Krousel-Wood M, Islam T, Webber LS, Re RN, Morisky DE, Muntner P. New medication adherence scale versus pharmacy fill rates in seniors with hypertension. Am J Manag Care. 2009 Jan;15(1):59-66.

Reference Type BACKGROUND
PMID: 19146365 (View on PubMed)

Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. JAMA. 2006 Dec 6;296(21):2563-71. doi: 10.1001/jama.296.21.joc60162. Epub 2006 Nov 13.

Reference Type BACKGROUND
PMID: 17101639 (View on PubMed)

McDonald HP, Garg AX, Haynes RB. Interventions to enhance patient adherence to medication prescriptions: scientific review. JAMA. 2002 Dec 11;288(22):2868-79. doi: 10.1001/jama.288.22.2868.

Reference Type BACKGROUND
PMID: 12472329 (View on PubMed)

Melzack R. The short-form McGill Pain Questionnaire. Pain. 1987 Aug;30(2):191-197. doi: 10.1016/0304-3959(87)91074-8.

Reference Type BACKGROUND
PMID: 3670870 (View on PubMed)

Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008 May;10(5):348-54. doi: 10.1111/j.1751-7176.2008.07572.x.

Reference Type BACKGROUND
PMID: 18453793 (View on PubMed)

Nathan A, Goodyer L, Lovejoy A, Rashid A. 'Brown bag' medication reviews as a means of optimizing patients' use of medication and of identifying potential clinical problems. Fam Pract. 1999 Jun;16(3):278-82. doi: 10.1093/fampra/16.3.278.

Reference Type BACKGROUND
PMID: 10439982 (View on PubMed)

O'Connor PJ. Improving medication adherence: challenges for physicians, payers, and policy makers. Arch Intern Med. 2006 Sep 25;166(17):1802-4. doi: 10.1001/archinte.166.17.1802. No abstract available.

Reference Type BACKGROUND
PMID: 17000934 (View on PubMed)

Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005 Aug 4;353(5):487-97. doi: 10.1056/NEJMra050100. No abstract available.

Reference Type BACKGROUND
PMID: 16079372 (View on PubMed)

Sakthong P, Chabunthom R, Charoenvisuthiwongs R. Psychometric properties of the Thai version of the 8-item Morisky Medication Adherence Scale in patients with type 2 diabetes. Ann Pharmacother. 2009 May;43(5):950-7. doi: 10.1345/aph.1L453. Epub 2009 Apr 14.

Reference Type BACKGROUND
PMID: 19366872 (View on PubMed)

Svarstad BL, Chewning BA, Sleath BL, Claesson C. The Brief Medication Questionnaire: a tool for screening patient adherence and barriers to adherence. Patient Educ Couns. 1999 Jun;37(2):113-24. doi: 10.1016/s0738-3991(98)00107-4.

Reference Type BACKGROUND
PMID: 14528539 (View on PubMed)

Touchette DR, Burns AL, Bough MA, Blackburn JC. Survey of medication therapy management programs under Medicare part D. J Am Pharm Assoc (2003). 2006 Nov-Dec;46(6):683-91. doi: 10.1331/1544-3191.46.6.683.touchette.

Reference Type BACKGROUND
PMID: 17176683 (View on PubMed)

van Mil JW, Westerlund LO, Hersberger KE, Schaefer MA. Drug-related problem classification systems. Ann Pharmacother. 2004 May;38(5):859-67. doi: 10.1345/aph.1D182. Epub 2004 Mar 30.

Reference Type BACKGROUND
PMID: 15054145 (View on PubMed)

Vasterling JJ, Proctor SP, Amoroso P, Kane R, Heeren T, White RF. Neuropsychological outcomes of army personnel following deployment to the Iraq war. JAMA. 2006 Aug 2;296(5):519-29. doi: 10.1001/jama.296.5.519.

Reference Type BACKGROUND
PMID: 16882958 (View on PubMed)

Institute for Healthcare Improvement. (2009).

Reference Type BACKGROUND

Burkhart PV, Sabate E. Adherence to long-term therapies: evidence for action. J Nurs Scholarsh. 2003;35(3):207. No abstract available.

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PMID: 14562485 (View on PubMed)

McNair, D., M. Lorr, et al. (1992). POMS Manual

Reference Type BACKGROUND

National Council on Patient Information and Education. (2008).

Reference Type BACKGROUND

Ware, J. E., K. K. Snow, et al. (1993). SF36 health survey: Manual and interpretation guide. Boston. MA, New England Medical Center

Reference Type BACKGROUND

Related Links

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http://www.talkaboutrx.org/documents/enhancing_prescription_medicine_adherence.pdf

National Council on Patient Information and Education. (2008). "Public policy \& adherence." Retrieved July 20, 2008

Other Identifiers

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W81XWH-09-1-0092

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2009-0936

Identifier Type: -

Identifier Source: org_study_id

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