SNaP Wound Care System Versus Traditional NPWT Device for Treatment of Chronic Wounds

NCT ID: NCT00951080

Last Updated: 2022-08-01

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

132 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-07-31

Study Completion Date

2011-03-31

Brief Summary

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The purpose of this study is to evaluate a novel negative pressure wound therapy (NPWT) device called the SNaP device compared to a traditional NPWT device for the treatment of lower extremity diabetic and venous ulcer wounds.

Detailed Description

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This is a prospective, randomized, two-arm, non-inferiority, multi-center study comparing negative pressure therapy wound healing outcomes between the SNaP Wound Care System and traditional NPWT systems.

Conditions

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Ulcers Wounds

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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SNaP Wound Care System

Group Type EXPERIMENTAL

SNaP Wound Care System

Intervention Type DEVICE

Wound dressing applications using customized system. Dressing applications changes per manufacturer recommendation.

Traditional NPWT System

Group Type ACTIVE_COMPARATOR

Traditional NPWT System

Intervention Type DEVICE

Standard wound dressing applications followed by negative pressure system application per manufacturer recommendations.

Interventions

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Traditional NPWT System

Standard wound dressing applications followed by negative pressure system application per manufacturer recommendations.

Intervention Type DEVICE

SNaP Wound Care System

Wound dressing applications using customized system. Dressing applications changes per manufacturer recommendation.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject has Venous Ulcer or Diabetic Ulcer with a surface area \< 100 sq. cm and \< 10 cm in widest diameter on lower extremity, but larger than 1 sq. cm
* Subject has wound present for \>30 days despite appropriate wound care
* Subject has adequate blood perfusion (Defined as either transcutaneous oxygen measurements of the dorsum of the foot \>30 mmHg or 0.7 \< ABI \<1.2)
* Subject has wound in location amendable to creation of airtight seal around wound using NPWT dressings
* Subject is able to understand and provide written consent
* Subject able to understand and provide written consent
* Male or non-pregnant female willing to have urine pregnancy test

Exclusion Criteria

* Subject has Active Infection (Redness, Swelling, Pain, Purulent Exudate)
* Subject has Untreated Osteomyelitis
* Subject has Allergy to Wound Care Products used in the study
* Subject has Malignancy, Burn, Collagen Vascular Disease, Sickle Cell, Vasculopathy, or Pyoderma Gangrenosum Origin of Wound
* Subject has Active Charcot Arthropathy of the Foot
* Subject has study wound location on toes or plantar surface of foot
* Subject has uncontrolled hyperglycemia (HbA1C \>12%)
* Subject has end stage renal disease requiring dialysis
* Subject is undergoing active chemotherapy treatment that inhibits wound healing
* Subject has had previous treatment with NPWT device, growth factors, hyperbaric oxygen, or bioengineered tissue product within 30 days of enrollment
* Subject has a \>30% wound surface area reduction in size at 1 week after screening visit
* Subject has any other condition that, in the opinion of the investigator, makes the subject inappropriate to take part in this study
* Subject is unwilling or unable to comply with protocol requirements
* Subject is pregnant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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3M

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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David G Armstrong, DPM, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

Southern Arizona Limb Salvage Alliance (SALSA)

Locations

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Hope Research Institute

Phoenix, Arizona, United States

Site Status

Southern Arizona Limb Salvage Alliance (SALSA)

Tucson, Arizona, United States

Site Status

Center for Clinical Research, Inc.

Castro Valley, California, United States

Site Status

Jay Mukker, DPM Inc.

Fresno, California, United States

Site Status

Palomar Pomerado Health Wound Care Center

Poway, California, United States

Site Status

O'Connor Wound Care Clinic

San Jose, California, United States

Site Status

John Muir Wound Care Center

Walnut Creek, California, United States

Site Status

Georgetown University Hospital

Washington D.C., District of Columbia, United States

Site Status

Bethesda Health City Wound Care Center

Boynton Beach, Florida, United States

Site Status

Wound Care on Wheels, LLC

Jacksonville, Florida, United States

Site Status

Osceola Regional Medical Center

Kissimmee, Florida, United States

Site Status

Weil Foot & Ankle Institute

Des Plaines, Illinois, United States

Site Status

LA Cardiovascular & Limb Salvage Center

Lafayette, Louisiana, United States

Site Status

University of North Carolina

Chapel Hill, North Carolina, United States

Site Status

The Christ Hospital, Wound Healing Center

Cincinnati, Ohio, United States

Site Status

New Bridge Medical Research Corporation

Warren, Pennsylvania, United States

Site Status

Southwest Washington Medical Center Wound Healing Center

Vancouver, Washington, United States

Site Status

Countries

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United States

References

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Armstrong DG, Marston WA, Reyzelman AM, Kirsner RS. Comparison of negative pressure wound therapy with an ultraportable mechanically powered device vs. traditional electrically powered device for the treatment of chronic lower extremity ulcers: a multicenter randomized-controlled trial. Wound Repair Regen. 2011 Mar-Apr;19(2):173-80. doi: 10.1111/j.1524-475X.2010.00658.x.

Reference Type RESULT
PMID: 21362084 (View on PubMed)

Other Identifiers

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SNP041609

Identifier Type: -

Identifier Source: org_study_id

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