Pneumatic Compression Treatment For Upper Extremity Acquired Lymphedema

NCT ID: NCT00951067

Last Updated: 2014-01-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2009-08-31

Study Completion Date

2014-02-28

Brief Summary

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The purpose of this study is to determine how well different treatments for acquired lymphedema work.

The study will compare 5 different non-invasive treatments for acquired lymphedema of the arm to see which treats lymphedema best.

Detailed Description

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This study will compare 5 non-invasive lymphedema treatments.

Patients will be assigned to either:

\- A combination of arm exercises, arm elevation, and wearing of a compression garment every day

OR

\- One of four possible pneumatic compression devices for just two hours every day.

Pneumatic compression devices are made up of an inflatable sleeve connected to a small controller unit that is plugged into the wall. They feel like having your blood pressure taken.

None of the treatments are experimental. None of the treatments are invasive. All the treatments are considered standard of care and are used in clinics throughout the United States. All of the treatments will be done at home.

The trial will last for 7 and 1/2 months and will require follow-up visits to monitor progress.

Conditions

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Lymphedema

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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Group A

Exercise, Elevation, and Garment Compression

Group Type ACTIVE_COMPARATOR

Exercise, Elevation, and Compression Garment

Intervention Type OTHER

Patients will be asked to daily:

* exercise
* elevate arm
* wear an arm compression garment

Group B

Pneumatic Compression Device (B)

Group Type ACTIVE_COMPARATOR

E0650 PCD with non-sequential waveform

Intervention Type DEVICE

Use of an E0650 PCD with non-sequential waveform for two hours every day.

Group C

Pneumatic Compression Device (C)

Group Type ACTIVE_COMPARATOR

E0651 PCD with sequential, non-gradient waveform

Intervention Type DEVICE

Use of an E0651 PCD with sequential, non-gradient waveform for two hours every day

Group D

Pneumatic Compression Device (D)

Group Type ACTIVE_COMPARATOR

E0652 PCD with sequential, gradient waveform

Intervention Type DEVICE

Use of an E0652 PCD with sequential, gradient waveform for two hours every day.

Group E

Pneumatic Compression Device (E)

Group Type ACTIVE_COMPARATOR

E0652 PCD with peristaltic pulse waveform

Intervention Type DEVICE

Use the E0652 PCD with peristaltic pulse waveform for two hours every day.

Interventions

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Exercise, Elevation, and Compression Garment

Patients will be asked to daily:

* exercise
* elevate arm
* wear an arm compression garment

Intervention Type OTHER

E0650 PCD with non-sequential waveform

Use of an E0650 PCD with non-sequential waveform for two hours every day.

Intervention Type DEVICE

E0651 PCD with sequential, non-gradient waveform

Use of an E0651 PCD with sequential, non-gradient waveform for two hours every day

Intervention Type DEVICE

E0652 PCD with sequential, gradient waveform

Use of an E0652 PCD with sequential, gradient waveform for two hours every day.

Intervention Type DEVICE

E0652 PCD with peristaltic pulse waveform

Use the E0652 PCD with peristaltic pulse waveform for two hours every day.

Intervention Type DEVICE

Other Intervention Names

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Brand: Huntleigh Flowtron Hydroven™ 3 Brand: Petite Basic System (Model 701A) Lympha Press Brand: Bio Compression Sequential Circulator 3008 NormaTec brand

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with acquired lymphedema of the arm.

Exclusion Criteria

* Refusal of consent
* Unlikely compliance with the research protocol
* Acute upper extremity DVT
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NormaTec Industries LP

INDUSTRY

Sponsor Role collaborator

Boston Children's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Arin K Greene, MD, MMSc

Role: PRINCIPAL_INVESTIGATOR

Boston Children's Hospital

Locations

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Children's Hospital Boston at Waltham

Waltham, Massachusetts, United States

Site Status

Countries

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United States

Other Identifiers

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AQ-UE-LYMPHEDMA-PCD-RCT

Identifier Type: -

Identifier Source: org_study_id

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