The Role of High Resolution-Computed Tomography (CT) in Tuberculosis (TB) Outbreak Investigation

NCT ID: NCT00889759

Last Updated: 2009-09-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

92 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-12-31

Study Completion Date

2009-04-30

Brief Summary

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The aim of this study is to evaluate the role of high-resolution computed tomography of the chest (HRCT) in the investigation of an outbreak of TB that developed in the South Korean army.

Detailed Description

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Outbreak investigation including tuberculin skin test (TST), QuantiFERON® TB Gold In-Tube (QFT), and simple chest radiography (CXR) will be performed. For participants with any abnormal findings in these tests, HRCT will be carried out. Active pulmonary TB is diagnosed based on sputum studies or HRCT findings. In addition, participants with positive results both in TST and QTF will be treated as having a latent TB infection (LTBI). TST and QTF were repeated in participants with positive result in one of these tests. CXR will be repeated in all participants at 3 and 6 months of follow-up.

Conditions

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Tuberculosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* All soldiers who assigned to the military battery where a tuberculosis outbreak occurred

Exclusion Criteria

* Soldiers who could not complete study
Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Armed Forces Capital Hospital, Republic of Korea

OTHER_GOV

Sponsor Role lead

Responsible Party

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Armed Forces Capital Hospital

Principal Investigators

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Jae-Joon Yim, MD

Role: PRINCIPAL_INVESTIGATOR

Seoul National University Hospital

References

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Lee SW, Jang YS, Park CM, Kang HY, Koh WJ, Yim JJ, Jeon K. The role of chest CT scanning in TB outbreak investigation. Chest. 2010 May;137(5):1057-64. doi: 10.1378/chest.09-1513. Epub 2009 Oct 31.

Reference Type DERIVED
PMID: 19880906 (View on PubMed)

Other Identifiers

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TBoutbreak

Identifier Type: -

Identifier Source: org_study_id

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