A Study for the Ocular Toxocariasis Patients With the Pulmonary Toxocariasis, and Ocular Toxocariasis Cohort
NCT ID: NCT03814837
Last Updated: 2019-01-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
400 participants
OBSERVATIONAL
2017-07-10
2020-07-31
Brief Summary
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Detailed Description
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In humans, two pathways of infection are known: first, ingestion of the eggs and second, larvae encapsulated in the tissues of the infected animal.
The encapsulated larvae hatch in the small intestine and pass through the barrier to the portal vein, the liver, the lung, the eye, etc. and remain as encapsulated larvae or survive for a period of time.
Infection into humans has been reported through ingestion of uncooked liver of cows, pigs, sheep, chickens, and meat (muscle).
When encapsulated larvae migrate to the body such as lungs, eosinophils activate and proliferate to eliminate the parasites.
They can be expressed as ground glass opacity (GGO) or nodular lesion by aggregated eosinophils, which are mistaken for lung cancer or pneumonia to be investigated.
Asthma exacerbation, cough and other symptoms of respiratory system could be revealed, but often asymptomatic.
In this study, the investigators defined pulmonary toxocariasis (PT) as a positive form of serum toxocara Ab and migrating pulmonary GGOs or nodular lesions in chest diagnostic image tests (chest X-ray, chest CT) from the patient.
Also ocular toxocariasis (OT) is defined by the clinical manifestation of intraocular infection by Toxocara larvae with a positive result of serum toxocara Ab.
Clinical manifestations of OT may also cause blindness of peripheral granuloma, optic neuritis, chorioretinitis, conjunctivitis, keratitis, iridocyclitis and cataract.
The investigators want to investigate the incidence of OT associated with PT in patients with chest diagnostic image tests (chest X-ray, chest CT) with migrating GGOs or nodular lesions. Also a cohort study is to track the results of treatment for diagnosed OT patients.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
* Patient who has positive result of Toxocara Ab
* Patient who has history of eating of law animal liver or meat
* Patient who has the chest diagnostic image tests (chest X-ray, chest CT) with migrating ground glass opacity or nodular lesions.
Exclusion Criteria
* Pregnant woman
* Malignant patient
* Patient who has pulmonary infectious lesion such as pneumonia, fungus and tuberculosis
* Patients who were diagnosed by benign or malignant pulmonary nodule
* Patient who was not consented
18 Years
ALL
No
Sponsors
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Ulsan University Hospital
OTHER
University of Ulsan
OTHER
Responsible Party
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Kwang Won Seo
Associate professor, division of pulmonology, dept. of internal medicine
Principal Investigators
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Kwang Won Seo, M.D.
Role: PRINCIPAL_INVESTIGATOR
Ulsan University Hospital
Locations
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Ulsan University Hospital, 877 Bangeojin Sunwhando-ro
Ulsan, , South Korea
Countries
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Central Contacts
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Facility Contacts
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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UUH 2017-06-012-001
Identifier Type: -
Identifier Source: org_study_id
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