The Dutch Acute Stroke Trial (DUST): Prediction of Outcome With Computed Tomography (CT) - Perfusion and CT-angiography
NCT ID: NCT00880113
Last Updated: 2012-06-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
1500 participants
OBSERVATIONAL
2009-05-31
Brief Summary
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Hypothesis:
The investigators hypothesize that combined CTP and CTA parameters can predict patient outcome in acute ischemic stroke.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Acute stroke
Patients over 18 years of age with acute stroke symptoms of less then 9 hours duration and no hemorrhage on non-contrast CT.
Non-contrast CT, CT-perfusion and CT-angiography
Included patients will undergo one additional combined CT-scan (NCCT, CTP and CTA) on day 3 (+/- 2 days).
Interventions
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Non-contrast CT, CT-perfusion and CT-angiography
Included patients will undergo one additional combined CT-scan (NCCT, CTP and CTA) on day 3 (+/- 2 days).
Eligibility Criteria
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Inclusion Criteria
* Admission \< 9 hours after onset of neurological deficit
* NIH Stroke Scale (NIHSS) of at least 2
* No absolute contraindications against intravenous contrast
* Informed consent from patient or family after admission scan
* Patients who awaken with stroke symptoms can only be included if they went to sleep without any stroke symptoms and the time from going to sleep until imaging is less than 9 hours
Exclusion Criteria
* Patients with known contrast allergy or kidney failure
* Patients with the known combination of renal insufficiency and heart failure (New York Heart Association (NYHA) IV) will be excluded for the CTP and CTA scan at 3 days; they will have a non-contrast CT (NCCT) at that time.
18 Years
ALL
No
Sponsors
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Dutch Heart Foundation
OTHER
UMC Utrecht
OTHER
Responsible Party
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University Medical Center Utrecht
Locations
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Academic Medical Center
Amsterdam, , Netherlands
Onze Lieve Vrouwe Gasthuis (OLVG)
Amsterdam, , Netherlands
VU Medical Center
Amsterdam, , Netherlands
Gelre Hospitals
Apeldoorn, , Netherlands
Alysis Zorggroep
Arnhem, , Netherlands
Catharina Hospital
Eindhoven, , Netherlands
Leiden University Medical Center
Leiden, , Netherlands
St. Antonius Hospital
Nieuwegein, , Netherlands
UMC St. Radboud
Nijmegen, , Netherlands
Erasmus Medical Center
Rotterdam, , Netherlands
St. Franciscus Gasthuis
Rotterdam, , Netherlands
Medical Center Haaglanden, location Westeinde
The Hague, , Netherlands
St. Elisabeth Hospital
Tilburg, , Netherlands
University Medical Center Utrecht
Utrecht, , Netherlands
Countries
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Central Contacts
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References
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Dankbaar JW, Horsch AD, van den Hoven AF, Kappelle LJ, van der Schaaf IC, van Seeters T, Velthuis BK; DUST Investigators. Prediction of Clinical Outcome After Acute Ischemic Stroke: The Value of Repeated Noncontrast Computed Tomography, Computed Tomographic Angiography, and Computed Tomographic Perfusion. Stroke. 2017 Sep;48(9):2593-2596. doi: 10.1161/STROKEAHA.117.017835. Epub 2017 Jul 17.
Luitse MJ, Velthuis BK, Kappelle LJ, van der Graaf Y, Biessels GJ; DUST Study Group. Chronic hyperglycemia is related to poor functional outcome after acute ischemic stroke. Int J Stroke. 2017 Feb;12(2):180-186. doi: 10.1177/1747493016676619. Epub 2016 Oct 26.
van den Wijngaard IR, Wermer MJ, Boiten J, Algra A, Holswilder G, Meijer FJ, Dippel DW, Velthuis BK, Majoie CB, van Walderveen MA. Cortical Venous Filling on Dynamic Computed Tomographic Angiography: A Novel Predictor of Clinical Outcome in Patients With Acute Middle Cerebral Artery Stroke. Stroke. 2016 Mar;47(3):762-7. doi: 10.1161/STROKEAHA.115.012279. Epub 2016 Jan 26.
van den Wijngaard IR, Boiten J, Holswilder G, Algra A, Dippel DW, Velthuis BK, Wermer MJ, van Walderveen MA. Impact of Collateral Status Evaluated by Dynamic Computed Tomographic Angiography on Clinical Outcome in Patients With Ischemic Stroke. Stroke. 2015 Dec;46(12):3398-404. doi: 10.1161/STROKEAHA.115.010354. Epub 2015 Nov 5.
Bennink E, Oosterbroek J, Horsch AD, Dankbaar JW, Velthuis BK, Viergever MA, de Jong HW. Influence of Thin Slice Reconstruction on CT Brain Perfusion Analysis. PLoS One. 2015 Sep 11;10(9):e0137766. doi: 10.1371/journal.pone.0137766. eCollection 2015.
Luitse MJ, Velthuis BK, Dauwan M, Dankbaar JW, Biessels GJ, Kappelle LJ; Dutch Acute Stroke Study Group. Residual high-grade stenosis after recanalization of extracranial carotid occlusion in acute ischemic stroke. Stroke. 2015 Jan;46(1):12-5. doi: 10.1161/STROKEAHA.114.007169. Epub 2014 Dec 9.
Fahmi F, Marquering HA, Borst J, Streekstra GJ, Beenen LF, Niesten JM, Velthuis BK, Majoie CB, vanBavel E; DUST study. 3D movement correction of CT brain perfusion image data of patients with acute ischemic stroke. Neuroradiology. 2014 Jun;56(6):445-52. doi: 10.1007/s00234-014-1358-7. Epub 2014 Apr 9.
Other Identifiers
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NL25625.041.08
Identifier Type: -
Identifier Source: secondary_id
2008T034
Identifier Type: -
Identifier Source: org_study_id
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