Autonomic Nervous Activity in Women With Gestational Diabetes

NCT ID: NCT00867022

Last Updated: 2009-03-23

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 80 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2004-08-31
• Study Completion Date: 2009-03-31

Brief Summary

Through complex hormonal pathways, insulin resistance can lead to the activation of the sympathetic nervous system, and vice versa. Schobel et al. showed that in PE patients, mus-cle sympathetic nerve activity (MSNA) is increased compared with normotensive pregnant and non-pregnant women. Studies assessing heart-rate variability and plasma noradrenalin concentrations also suggest increased sympathetic activity in PE. It has been hypothesized that sympathetic over-activity is a precursor of PE, normally compensated for by vasodilating mechanisms, but resulting in PE when the mechanisms fail. In addition to sympathetic activity, various markers of inflamma-tion are also associated with reduced insulin sensitivity, suggesting that chronic sub-clinical inflamma-tion could be part of the insulin resistance syndrome. The role of sympathetic over-activity and inflammatory markers in gestational diabetes has not been investigated

Conditions

Gestational Diabetes

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

1

Women with gestational diabetes

No interventions assigned to this group

2

Pregnant women without gestational daibetes

No interventions assigned to this group

3

Women with gestational diabetes and hypertension

No interventions assigned to this group

4

Non pregnant women

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Clinical diagnosis of gestational diabetes (OGTT) with or without BP > 140/90.
• Pregnant control with normal OGTT-

Exclusion Criteria

• Smoking
• Uncontrolled hypertension
• Diabetes
• Medication affecting sympathetic activity

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Helsinki

OTHER

Sponsor Role: lead

Responsible Party

Helsinki University Hospital

Locations

Department of Obstet and Gyn, Helsinki University Hospital

Helsinki, Uusimaa, Finland

Countries

Finland

Other Identifiers

GESTSYMPIS

Identifier Type: -

Identifier Source: org_study_id