Role of Adipokines in Glucose Regulation During Pregnancy and in Fetal Development

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

1034 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-01-31

Study Completion Date

2025-09-30

Brief Summary

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This study includes 2 phases. During phase 1, pregnant women are followed over the course of pregnancy. The phase 2 is a follow-up of the mother-child dyad at 3, 5 and 10-12 year after delivery.

The purpose of this phase 1 is to :

* assess the contribution and interactions of adipokines in the development of insulin resistance during pregnancy and gestational diabetes;
* assess levels of maternal adipokines as determinants of development and fetal growth;
* determine the genetic variations that influence levels of adipokines and glucose regulation during pregnancy and in newborns.

The purpose of this phase 2 is to:

* identify DNA methylation variations at birth that are predictive of childhood overweight/obesity.
* identify maternal characteristics associated with DNA methylation variations predictive of childhood overweight/obesity.
* establish whether the loci predictive of childhood overweight/obesity at birth are still differentially methylated at 5 years of age (samples collected at 5 years of age).
* identify DNA methylation variations at birth that are predictive of childhood neurodevelopment problems at 3, 5 and 10 years of age.

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Detailed Description

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Conditions

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Gestational Diabetes Insulin Resistance Obesity Prevention

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Phase 1: Pregnant women

No interventions assigned to this group

Phase 2: Mother-offspring dyad

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* age ≥ 18 yrs
* gestational age between 6 and 13 weeks from last menstrual period
* no recognized diabetes or drugs interfering with glucose metabolism
* alcohol \< 2 drinks/day
* not involved in regular high intensity physical activity
* otherwise good health status