Effects of Stress on Glucose Tolerance During Pregnancy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

203 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-10-31

Study Completion Date

2017-09-30

Brief Summary

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The objective of the study is to investigate the effect of stress on glucose tolerance during pregnancy.

The main objectives of the study are to investigate if various measures of stress (stressful life events, the perceived level of stress and the cortisol or copeptin concentrations) differ between pregnant women with and without gestational diabetes during the end of the second/beginning of the third trimester when presenting for their routine glucose tolerance testing.

Secondary objectives are the link between these different stress measures and the routinely measured fasting and stimulated glucose levels during the oral glucose tolerance test.

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Detailed Description

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Hypotheses in this study, 3 primary hypotheses will be tested.

1. Women with gestational diabetes have more life events compared to pregnant women without gestational diabetes.
2. Women with gestational diabetes have higher perceived level of stress and anxiety compared to pregnant women without gestational diabetes.
3. Women with gestational diabetes have higher measures of cortisol levels in the saliva and in the nailfolds and higher plasma copeptin levels compared to pregnant women without gestational diabetes.

Secondary objectives:

1\. To test the link between these stress measures and the fasting and stimulated glucose levels during the oral glucose tolerance test.

Conditions

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Pregnancy Stress Gestational Diabetes

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Women with gestational diabetes

Women with gestational diabetes diagnosed by clinically routine 75 g oral glucose tolerance testing

No interventions assigned to this group

Women without gestational diabetes

Women without gestational diabetes diagnosed by clinically routine 75 g oral glucose tolerance testing

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* All pregnant women who are undergoing a 75 g oral glucose tolerance test at the "Maternité" of CHUV at 24-30 weeks of gestation between October 2012 and April 2013

Exclusion Criteria

* Pregnant woman who has the use if medications that influence either the cortisol and /or the glucose levels
* Pregnant woman who has the inability to fill out the questionnaires with assistance

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes