Muscle Strength and Exercise Capacity in Sarcoidosis Patients

NCT ID: NCT00854672

Last Updated: 2012-04-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

124 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-31

Study Completion Date

2011-09-30

Brief Summary

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The aim of this study is to examine exercise capacity, muscle strength and fatigue in sarcoidosis. In this longitudinal study the changes in prevalence of exercise intolerance, reduced muscle strength and fatigue will be established in a two-year follow-up. Also the relation between these physical impairments in time and other clinical parameters, such as QOL, will be established.

Detailed Description

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The aim of this study is to examine exercise capacity, muscle strength and fatigue in sarcoidosis. In this longitudinal study the changes in prevalence of exercise intolerance, reduced muscle strength and fatigue will be established in a two-year follow-up. Also the relation between these physical impairments in time and other clinical parameters, such as QOL, will be established.

Study design: sarcoidosis patients referred to the ild care team of outpatient clinic of the department of Respiratory Medicine of the MUMC and also participated in the baseline study between November 2008 and September 2009 will be included in this longitudinal study. A six-minute walk test and peripheral muscle strength measurements (included in the regular clinical work-up of sarcoidosis patients) will be performed under supervision of a physical therapist at the department of physical therapy of the MUMC. Moreover, the patients will be asked to complete the WHOQOL-bref questionnaire and the Fatigue Assessment Scale. A maximum of 124 patients will be included.

Conditions

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Sarcoidosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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sarcoidosis patients

Sarcoidosis patients referred to the ild care team of the outpatient clinic of the department of Respiratory Medicine of the MUMC and also participated in the baseline study between November 2008 and September 2009 will be included in this study

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* diagnosed sarcoidosis according to WASOG/ATS/ERS guidelines

Exclusion Criteria

* not being able to walk
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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ild care foundation

OTHER

Sponsor Role collaborator

Maastricht University Medical Center

OTHER

Sponsor Role lead

Responsible Party

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marjolein drent

Prof. Marjolein Drent

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Rik Marcellis, MSc

Role: PRINCIPAL_INVESTIGATOR

Maastricht University Medical Center

Marjolein Drent, MD, PhD

Role: STUDY_CHAIR

Maastricht University Medical Center and University Maastricht

Ton Lenssen, MSc, PhD

Role: STUDY_DIRECTOR

Maastricht UMC and University of Maastricht

Locations

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Maastricht University Medical Center

Maastricht, , Netherlands

Site Status

Countries

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Netherlands

References

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Marcellis RG, Lenssen AF, Elfferich MD, De Vries J, Kassim S, Foerster K, Drent M. Exercise capacity, muscle strength and fatigue in sarcoidosis. Eur Respir J. 2011 Sep;38(3):628-34. doi: 10.1183/09031936.00117710. Epub 2011 Mar 24.

Reference Type RESULT
PMID: 21436356 (View on PubMed)

Marcellis RG, Lenssen AF, Kleynen S, De Vries J, Drent M. Exercise capacity, muscle strength, and fatigue in sarcoidosis: a follow-up study. Lung. 2013 Jun;191(3):247-56. doi: 10.1007/s00408-013-9456-6. Epub 2013 Apr 5.

Reference Type DERIVED
PMID: 23558599 (View on PubMed)

Related Links

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http://www.ildcare.eu

official site of ild care foundation which facilitates research on patients with interstitial lung disease

http://www.azm.nl

official site of the Maastricht University Medical Centre

Other Identifiers

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MEC 09-4-007

Identifier Type: -

Identifier Source: org_study_id

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