Genetic Susceptibility to Bladder Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

6086 participants

Study Classification

OBSERVATIONAL

Study Start Date

1998-02-10

Study Completion Date

2026-08-01

Brief Summary

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This clinical research study will identify biologic and lifestyle factors which increase a person's risk of developing specific cancer. Researchers propose to conduct a case-control study examining interindividual differences in susceptibility to tobacco carcinogenesis as predictors of bladder cancer risk. We will measure susceptibility to tobacco carcinogenesis and this will include studies of the genetic modulation of carcinogen activation and detoxification and of chromosome sensitivity to tobacco mutagens.

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Detailed Description

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Researchers propose to conduct a case-control study examining interindividual differences in susceptibility to tobacco carcinogenesis as predictors of bladder cancer risk. We will measure susceptibility to tobacco carcinogenesis and this will include studies of the genetic modulation of carcinogen activation and detoxification and of chromosome sensitivity to tobacco mutagens.

Conditions

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Bladder Cancer

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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Participants with Bladder Cancer

Patients diagnosed with superficial or muscle-invasive bladder cancer. Specimens, personal and follow-up telephone interviews will be collected and conducted.

Interviews

Intervention Type BEHAVIORAL

Data collected by personal interview for Epidemiology and Nutrition Questionnaires, with personal and follow-up telephone interviews.

Interventions

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Interviews

Data collected by personal interview for Epidemiology and Nutrition Questionnaires, with personal and follow-up telephone interviews.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Subject has a histologically confirmed diagnosis of superficial or muscle-invasive bladder cancer
* Subject is a Texas resident.
* Subject can understand English or a qualified translator is available for the interview.
* Subjects of any age, gender, or ethnicity are eligible to participate in the study.
* Subject consents to participate in the study.

Exclusion Criteria

* Subject has had prior treatment with systemic chemotherapy or radiotherapy in the past 6 months.
* Subject has been diagnosed with superficial or muscle-invasive bladder cancer more than twelve months ago.

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes