DNA Repair and Genetic Susceptibility to Lung Cancer

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

218 participants

Study Classification

OBSERVATIONAL

Study Start Date

2003-02-11

Study Completion Date

2023-03-24

Brief Summary

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The purpose of this study is to help us better understand the cellular changes that may lead to the development of lung cancer. We want to compare people with a second primary lung cancer with those who have only a first primary lung cancer. We hope to use the information obtained in this study as the basis for future studies and will not regard the results from this study as final.

We will analyze your blood cells and DNA to measure the changes in several genes that we believe may be involved in lung cancer. We also want to evaluate the capacity for your DNA to repair itself.

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Detailed Description

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Conditions

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Lung Cancer Single Primary Lung Cancer Second Primary Lung Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

second primary lung cancer

Blood draw and Questionnaires

Intervention Type OTHER

Pt will have three green top tubes of blood drawn. The questionnaire will be filled out by the study subject. This may be completed at home and mailed in a provided stamped addressed envelope if the patient prefer, or obtained by phone interview with a research assistant.

2

single primary lung cancer

Blood draw and Questionnaires

Intervention Type OTHER

Pt will have three green top tubes of blood drawn. The questionnaire will be filled out by the study subject. This may be completed at home and mailed in a provided stamped addressed envelope if the patient prefer, or obtained by phone interview with a research assistant.

Interventions

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Blood draw and Questionnaires

Pt will have three green top tubes of blood drawn. The questionnaire will be filled out by the study subject. This may be completed at home and mailed in a provided stamped addressed envelope if the patient prefer, or obtained by phone interview with a research assistant.

Intervention Type OTHER

Blood draw and Questionnaires

Pt will have three green top tubes of blood drawn. The questionnaire will be filled out by the study subject. This may be completed at home and mailed in a provided stamped addressed envelope if the patient prefer, or obtained by phone interview with a research assistant.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Cases will be eligible for inclusion if:
* They have been diagnosed with a second primary lung cancer, and
* They speak English or a language for which we have a translated consent form, and
* They understand and agree to sign informed consent, and
* They agree to give us a blood sample, and
* They agree to give us a tissue sample when part of normal clinical procedures, and
* They agree to complete the study questionnaires, and
* They agree to have their pathology information reviewed. This could include biopsy specimens.

Controls will be eligible for inclusion if

* They have been diagnosed with a first primary lung cancer, and
* They speak English or a language for which we have a translated consent form, and
* They understand and agree to sign informed consent, and
* They agree to give us a blood sample, and
* They agree to give us a tissue sample when part of normal clinical procedures, and
* They agree to complete the study questionnaires,
* They agree to have their pathology information reviewed. This will could include biopsy specimens.

* Control subjects who have a history of another cancer, other than nonmelanoma skin cancer or a first primary lung cancer, will not be eligible for this study.
* Control subjects who otherwise meet the eligibility requirements above but who have had chemotherapy and/or are currently being treated with chemotherapy will be excluded from the functional assay, but not from the genotyping.

Eligible Sex

ALL

Accepts Healthy Volunteers

No