Genetic Susceptibility to Lung Cancer in Never Smokers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

238 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-06-30

Study Completion Date

2026-06-30

Brief Summary

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The purpose of this study is to help us better understand the cellular changes that may lead to the development of lung cancer. We want to compare people who have never smoked and yet have been diagnosed with lung cancer to never smokers who have not developed lung cancer. We hope to use the information obtained in this study as the basis for future studies and will not regard the results from this study as final.

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Detailed Description

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Conditions

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Lung Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1

NEVER SMOKERS WITH LUNG CANCER

Questionaire, blood sample

Intervention Type BEHAVIORAL

Provide 30ml blood for laboratory assays Complete Health Questionnaire

2

NEVER SMOKERS WITHOUT ANY CANCER

Questionaire, Blood sample

Intervention Type BEHAVIORAL

Provide 30ml blood for laboratory assays Complete Health Questionnaire

Interventions

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Questionaire, blood sample

Provide 30ml blood for laboratory assays Complete Health Questionnaire

Intervention Type BEHAVIORAL

Questionaire, Blood sample

Provide 30ml blood for laboratory assays Complete Health Questionnaire

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Cases will be eligible for inclusion if:
* They have been diagnosed with a lung cancer or have had previous surgical treatment for their lung cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and
* They have had no prior chemotherapy or radiation treatment within the last year (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected)
* They speak and read English
* They understand and agree to sign informed consent, and
* They agree to give us a blood sample, and
* They agree to complete the study questionnaire, and
* They agree to have their pathology information reviewed by study personnel.
* Controls will be eligible for inclusion if:
* They have not been diagnosed with any type of cancer, exclusive of nonmelanoma skin cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not regular cigar or pipe smokers, and
* They speak and read English
* They understand and agree to sign informed consent, and
* They agree to give us a blood sample, and
* They agree to complete the study questionnaire.

* All individuals who otherwise meet the eligibility requirements above, but who have had chemotherapy or radiation therapy within 1 year of evaluation will be excluded (Exception: genotyping analysis/screening can be performed on specimens from individuals who had chemo/radiation treatment within the last year as germline DNA will not be affected).

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes