Genomic Structural Variation in Cancer Susceptibility

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

1275 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-10-31

Study Completion Date

2026-10-31

Brief Summary

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This study will look for new types of gene changes that may be related to cancer in some patients. Some gene changes (mutations) are passed on from parents to offspring (child). Other gene changes are new and are seen for the first time in a child. They are not seen in the parent.

Some of these gene changes may cause cancers in the offspring. We will look for gene changes by studying patients with cancer their parents and family members without cancer. In this study, we will be able to find gene changes that occur in the cancer patient but not in the rest of the family. Knowing the role that new gene changes play in cancer risk may help us find people at a higher risk of getting cancer.

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Detailed Description

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Conditions

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Breast Cancer Colon Cancer Germ Cell Cancer Neuroblastoma Rectal Cancer Sarcoma

Study Design

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Observational Model Type

FAMILY_BASED

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

* Proband must have living unaffected biologic mother and father available and eligible for participation in the study with one of the following (both incident and prevalent cases will be collected):

* Colorectal cancer diagnosed at or under the age of 50.
* Breast cancer diagnosed at or under the age of 45.
* Germ cell tumor diagnosed at or under the age of 40.
* Pediatric cancer of any type diagnosed at or under the age of 21
* Adult cancer or pre-neoplastic condition of any type diagnosed at or under the age of 40
* Cancer at any age in 2 or more siblings suggestive of a genetic etiology, such as brothers with testicular germ cell tumor or sisters with breast cancer and ovarian cancer
* Parents:

* Must be the biologic mother and biologic father of affected proband.
* In certain clinical situations, parent(s) with cancer may be included at the discretion of the Principal Investigator, if the Principal Investigator deems that the etiology of cancer in the parent(s) and proband are biologically unrelated.
* Sibling(s):

* Must be age 18 or older and have same biologic parents as proband.