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An Investigation of Small Intestinal Carcinoid Carcinoma in Families

NCT ID: NCT00662168

Last Updated: 2008-04-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

8 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-31

Study Completion Date

2008-11-30

Brief Summary

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This proposed pilot study is to conduct detailed interviews into the medical, environmental, and family histories The second phase of this study project is to and to collect blood specimen to obtain DNA. The Blood specimen and DNA will be processed by the Rutgers University Cell and DNA Repository (RUCDR) and stored for a second phase of this pilot. The purpose is to rule out Familial Multiple Endocrine Neoplasia (MEN 1), and succinate dehydrogenase complex, subunit D (SDHD), gene inactivation thought to be associated with different types of carcinoid cancer.

Detailed Description

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There have not been any studies published which specifically describe the medical, environmental, and genetic factors in carcinoid tumors cases that have carcinoid in family members. While rare, with an incidence of four per 100, 000, carcinoid represents the most frequent malignancy affecting the small intestine. Because nearly half (49%) of the cases of gastrointestinal carcinoid tumors have hepatic metastasis at diagnosis, identification of the risk factors associated with carcinoid has the potential to increase early diagnosis and cure. Carcinoid tumors are thought to occur spontaneously and not associated with an inherited genetic abnormality that would increase a family member's risk for developing carcinoid cancer. There is a known inherited genetic abnormality that is associated with bronchial carcinoid tumors but only less than 10%. Gastrointestinal carcinoid tumors are not thought to be associated with a inherited genetic abnormality. There have been several small studies that have examined gastrointestinal carcinoid in multiple family members. It remains uncertain if these cases of carcinoid in multiple family members are characteristic of a heritable or environmental etiology. Most carcinoid cancer is not inherited; however, less than 10% of neuroendocrine carcinoid cancer is thought to be due to a change (called a "mutation") in a gene inherited from a parent. There are several genes that are suspected to be associated with carcinoid cancer, two of interest in this study is the Multiple Endocrine Neoplasia Type1 (MEN1), and succinate dehydrogenase complex, subunit D (SDHD) genes.

Conditions

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Carcinoid Carcinoma

Keywords

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carcinoid familial Collect and describe information about the medical and environmental factors associated with each cases of carcinoid carcinoma Develop a genogram representing the family cancer history of cases of Carcinoid.

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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observation

Individuals with a diagnosis of carcinoid carcinoma

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. Over the age of 18 years
2. History of biopsy confirmed small intestinal carcinoid tumor
3. English speaking
4. Mentally and emotionally capable of answering questions
5. Willing and available for study participation
6. At least one first-degree family member with carcinoid tumor

Exclusion Criteria

1. If you are under the age of 18 years,
2. If you have any mental or memory impairments
3. If you are unable to understand the information in the informed consent document.
Minimum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rutgers University

OTHER

Sponsor Role lead

Responsible Party

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Rutgers University

Principal Investigators

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Nancy Gardner, PhD

Role: PRINCIPAL_INVESTIGATOR

Rutgers University

Locations

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Rutgers University College of Nursing

Newark, New Jersey, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Nancy Gardner, PhD

Role: CONTACT

Phone: 973-991-1302

Email: [email protected] or [email protected]

Facility Contacts

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Nancy Gardner, PhD

Role: primary

Other Identifiers

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08-151

Identifier Type: -

Identifier Source: org_study_id