Study of Genes and the Environment in Patients With Colorectal Cancer in the East Anglia Region of the United Kingdom
NCT ID: NCT00757965
Last Updated: 2013-08-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
2000 participants
OBSERVATIONAL
2008-02-29
Brief Summary
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PURPOSE: This study is looking at genetic susceptibility for cancer and interactions between genes and the environment in patients with colorectal cancer.
Detailed Description
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* To obtain epidemiological information and biological material on a population based series of colorectal cancer cases.
* To define the proportion of colorectal cancer incidence attributable to mutations in known predisposing genes such as MLH1 and MSH2.
* To establish whether mutations at other loci may predispose to colorectal cancer, by comparing the frequency of alteration candidate genes in colorectal cancer patients with the corresponding frequency in cancer-free controls identified through the European Prospective Investigation of Cancer (EPIC) study.
OUTLINE: This is a multicenter study.
Patients complete an epidemiological questionnaire. The questionnaire also requests identifying information about the patient's first-degree relatives.
Blood samples are collected from patients. DNA is extracted from these blood samples, from samples collected from cancer-free control participants in MREC-SEARCH-CONTROL, and from additional controls through the European Prospective Investigation of Cancer (EPIC) study (a population-based study of diet and health based in Norfolk, East Anglia). DNA samples are analyzed for polymorphisms of low penetrance cancer susceptibility genes.
In addition to the colorectal cancer patients recruited for this study, patients with breast, ovarian, prostate, colorectal, bladder, kidney, pancreatic, brain, and esophageal cancer, malignant melanoma, and lymphoma cancer are recruited for the following related clinical trials: MREC-SEARCH-BREAST, MREC-SEARCH-OVARIAN, MREC-SEARCH-PROSTATE, MREC-SEARCH-ENDOMETRIAL, and MREC-SEARCH-CANCER.
Conditions
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Keywords
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Interventions
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polymorphism analysis
laboratory biomarker analysis
questionnaire administration
Eligibility Criteria
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Inclusion Criteria
* Diagnosis of colorectal cancer within the past 5 years
* Identified in the East Anglia region of the United Kingdom
PATIENT CHARACTERISTICS:
* Identified by the patient's general practitioner as fit to contact for this study
* No serious mental illness or retardation
PRIOR CONCURRENT THERAPY:
* Not specified
18 Years
69 Years
ALL
No
Sponsors
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Cancer Research UK
OTHER
Principal Investigators
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Paul Pharoah, MD
Role: STUDY_CHAIR
Cancer Research UK
Locations
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University of Cambridge Cancer Research UK
Cambridge, England, United Kingdom
Countries
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Facility Contacts
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Contact Person
Role: primary
Other Identifiers
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MREC-SEARCH-COLORECTAL
Identifier Type: -
Identifier Source: secondary_id
MREC-07/MRE05/17
Identifier Type: -
Identifier Source: secondary_id
CDR0000598882
Identifier Type: -
Identifier Source: org_study_id