Genetic Study of Familial Factors in Patients With Colon Cancer
NCT ID: NCT00055848
Last Updated: 2016-07-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
600 participants
OBSERVATIONAL
2001-12-31
2010-10-31
Brief Summary
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PURPOSE: Clinical trial to study the cancer-related genes in patients who have colon cancer or adenomatous polyps.
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Detailed Description
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* Identify human colon neoplasia susceptibility genes in patients with colon cancer or adenomatous polyps.
* Correlate the inheritance of novel susceptibility alleles for adenomatous polyposis of the colon with colon neoplasia in these patients.
* Correlate colon neoplasia susceptibility with the presence of COX-2, sPLA2, and DNMT genes in these patients.
* Identify a novel gene that governs increased susceptibility to colon adenoma and cancer in the genome of these patients.
Conditions
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Study Design
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CASE_ONLY
PROSPECTIVE
Study Groups
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Group 1
Patients donate blood samples for analysis of colorectal susceptibility genes. Patients also complete a questionnaire regarding family cancer history.
A certificate of confidentiality protecting the identity of research participants in this project has been issued by the National Cancer Institute.
Participants do not receive the results of the genetic testing, and the results do not influence the type or duration of treatment.
cytogenetic analysis
gene mapping
microarray analysis
Interventions
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cytogenetic analysis
gene mapping
microarray analysis
Eligibility Criteria
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Inclusion Criteria
Age
* 70 and under at diagnosis
Other
* No significant psychiatric illness that would preclude giving informed consent
* No inflammatory bowel disease (in patient or sibling)
70 Years
ALL
No
Sponsors
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National Cancer Institute (NCI)
NIH
Alliance for Clinical Trials in Oncology
OTHER
Responsible Party
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Principal Investigators
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Monica M. Bertagnolli, MD
Role: STUDY_CHAIR
Dana-Farber/Brigham and Women's Cancer Center
Locations
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Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, United States
Countries
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Other Identifiers
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CALGB-150008
Identifier Type: -
Identifier Source: secondary_id
CDR0000271314
Identifier Type: REGISTRY
Identifier Source: secondary_id
CALGB-150008
Identifier Type: -
Identifier Source: org_study_id
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