A Study of Once Monthly Intravenous Mircera for the Maintenance Treatment of Dialysis Patients With Chronic Renal Anemia.

NCT ID: NCT00737464

Last Updated: 2017-12-07

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

132 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-08-26

Study Completion Date

2009-09-12

Brief Summary

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This single arm study will evaluate the maintenance of hemoglobin levels, safety and tolerability of once-monthly intravenous administration of Mircera in dialysis patients with chronic renal anemia. Patients will receive intravenous Mircera (120, 200 or 360 micrograms) every four weeks depending on the previous dose of epoetin alfa administered in the week preceding first study drug administration. Patients will be treated for 12 weeks with follow up 2 weeks after the last treatment visit. The anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.

Detailed Description

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Conditions

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Anemia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Mircera

Participant with chronic renal anemia will receive methoxy polyethylene glycol-epoetin beta \[Mircera\] intravenously (IV) \[(120, 200 or 360 micrograms (mcg)\] every 4 weeks for 12 weeks.

Group Type EXPERIMENTAL

methoxy polyethylene glycol-epoetin beta [Mircera]

Intervention Type DRUG

iv (120, 200 or 360 micrograms) every 4 weeks for 12 weeks.

Interventions

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methoxy polyethylene glycol-epoetin beta [Mircera]

iv (120, 200 or 360 micrograms) every 4 weeks for 12 weeks.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* male or female patients, \>=18 years of age;
* chronic renal anemia;
* Hb concentration 10.5g/dL - 12.5g/dL;
* continuous intravenous maintenance therapy with epoetin alfa at the same dosing interval during the previous 2 months.

Exclusion Criteria

* blood transfusion within the previous 2 months;
* poorly controlled hypertension;
* significant acute or chronic bleeding;
* active malignant disease;
* congestive heart failure (NYHA Class IV).
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Indraprastha Apollo Hospitals

New Delhi, National Capital Territory of Delhi, India

Site Status

Manipal Institute of Nephrology and Urology; Nephrology

Bangalore, , India

Site Status

Columbia Asia Medical Centre - Hebbal; Nephrology

Bangalore, , India

Site Status

Tanker Foundation

Chennai, , India

Site Status

MIOT Institute of Nephrology ; Nephrology

Chennai, , India

Site Status

Madras Medical Mission Hospital

Chennai, , India

Site Status

International Hospital

Guwahati, , India

Site Status

Kamineni Hospitals; Nephrology

Hyderabad, , India

Site Status

Nizam's Institute of Medical Sciences; Nephrology

Hyderabad, , India

Site Status

Regency Hospital Ltd.; Nephrology

Kanpur, , India

Site Status

Wockhardt Hospital and Kidney Institute; Nephrology

Kolkata, , India

Site Status

Meerut Kidney Hospital

Meerut, , India

Site Status

Silver Oaks Hospital; Nephrology

Mohali, , India

Site Status

Apex Kidney Care

Mumbai, , India

Site Status

Lancelot Dialysis Center

Mumbai, , India

Site Status

Fortis Flt. Lt. Rajan Dhall Hospital; Nephrology

New Delhi, , India

Site Status

Ruby Hall Clinic

Pune, , India

Site Status

Countries

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India

Other Identifiers

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ML21810

Identifier Type: -

Identifier Source: org_study_id