A Study Comparing Mircera and Epoetin Beta for the Treatment of Anemia in Dialysis Patients With Chronic Kidney Disease.

NCT ID: NCT00442793

Last Updated: 2016-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

265 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-05-31

Study Completion Date

2010-05-31

Brief Summary

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This 2 arm study will compare the effect on hemoglobin response of Mircera and epoetin beta, in patients with chronic renal anemia who are on dialysis. Eligible patients will be randomized to receive either Mircera (0.4 micrograms/kg i.v. every 2 weeks) or epoetin beta (3 times weekly, according to approved labelling). The anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals.

Detailed Description

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Conditions

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Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

methoxy polyethylene glycol-epoetin beta [Mircera]

Intervention Type DRUG

0.4 micrograms/kg iv every 2 weeks

2

Group Type ACTIVE_COMPARATOR

Epoetin beta

Intervention Type DRUG

As prescribed, 3 times weekly

Interventions

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Epoetin beta

As prescribed, 3 times weekly

Intervention Type DRUG

methoxy polyethylene glycol-epoetin beta [Mircera]

0.4 micrograms/kg iv every 2 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients, \>=18 years of age;
* chronic renal anemia requiring dialysis;
* maintenance hemodialysis or peritoneal dialysis for \>=2 weeks before and during screening;
* adequate iron status.

Exclusion Criteria

* previous epoetin treatment within 8 weeks prior to screening;
* failing renal graft in place;
* bleeding episode necessitating transfusion within 8 weeks prior to screening;
* poorly controlled hypertension;
* previous treatment with Mircera.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Beijing, , China

Site Status

Beijing, , China

Site Status

Beijing, , China

Site Status

Chengdu, , China

Site Status

Guangzhou, , China

Site Status

Guangzhou, , China

Site Status

Hangzhou, , China

Site Status

Nanjing, , China

Site Status

Shanghai, , China

Site Status

Shanghai, , China

Site Status

Shanghai, , China

Site Status

Shanghai, , China

Site Status

Shanghai, , China

Site Status

Hong Kong, , Hong Kong

Site Status

Countries

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China Hong Kong

Other Identifiers

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ML20680

Identifier Type: -

Identifier Source: org_study_id