A Study for Monthly Methoxy Polyethylene Glycol-Epoetin Beta Treatment in Patients With Chronic Renal Anaemia

NCT ID: NCT01066000

Last Updated: 2017-11-13

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

PHASE4

Total Enrollment

33 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-10-31

Study Completion Date

2011-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This open-label single-arm study will evaluate the efficacy, safety and tolerability of methoxy polyethylene glycol epoetin beta on long-term maintenance of haemoglobin levels in patients with chronic renal anaemia. Patients will receive methoxy polyethylene glycol-epoetin beta intravenously once monthly at initial doses of either 120 micrograms or 200 micrograms or 360 micrograms in the titration phase of 16 weeks with a potential dose adjustment in the evaluation phase of 8 weeks. The anticipated time on study treatment is 24 weeks. The target sample size is 50-100 patients.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Anemia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Mircera

Group Type EXPERIMENTAL

methoxy polyethylene glycol-epoetin beta [Mircera]

Intervention Type DRUG

initial doses of either 120 micrograms or 200 micrograms or 360 micrograms, once monthly

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

methoxy polyethylene glycol-epoetin beta [Mircera]

initial doses of either 120 micrograms or 200 micrograms or 360 micrograms, once monthly

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Adults \>/=18 years of age
* Chronic renal anaemia
* Haemoglobin concentration between 10 and 12 g/dL at screening
* Adequate iron status
* Continuous intravenous maintenance short-acting therapy with same dosing interval for 8 weeks prior to screening
* Regular long-term haemodialysis therapy for at least 12 weeks prior to screening

Exclusion Criteria

* Change in haemoglobin concentration \>/=2 g/dL during screening
* Transfusion of red blood cells less than 8 weeks prior to screening
* Poorly controlled hypertension
* Relevant acute or chronic bleeding requiring treatment less than 8 weeks prior to screening
* Active malignant disease
* Haemolysis
* Haemoglobinopathies
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Advent Hospital; Kidney and Hipertension

Bandung, , Indonesia

Site Status

Sanglah Hospital; Kidney and Hipertension

Denpasar, , Indonesia

Site Status

Rumah Sakit Pgi Cikini; Renal & Hypertension

Jakarta, , Indonesia

Site Status

Cipto Mangunkusumo Hospital; Renal and Hypertension division, Internal Medecine Department

Jakarta, , Indonesia

Site Status

Pelni Hospital; Kidney and Hipertension

Jakarta, , Indonesia

Site Status

Pondok Indah Hospital; Kidney and Hipertension

Jakarta, , Indonesia

Site Status

Pantai Indah Kapuk Hospital; Kidney and Hipertension

Jakarta, , Indonesia

Site Status

Klinik Spesialis Ginjal dan hipertensi Rasyida; Renal and Hypertension

Medan, , Indonesia

Site Status

Pirngadi; Renal and Hypertension

Medan, , Indonesia

Site Status

Telogorejo Hospital; Renal and Hypertension

Semarang, , Indonesia

Site Status

Dokter Soetomo Hospital

Surabaya, , Indonesia

Site Status

PHC Hospital; Renal and Hypertension

Surabaya, , Indonesia

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Indonesia

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

ML21736

Identifier Type: -

Identifier Source: org_study_id