A Study of Mircera for the Treatment of Anemia in Dialysis Patients

NCT ID: NCT00077597

Last Updated: 2016-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

182 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-02-29

Study Completion Date

2006-06-30

Brief Summary

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This study will assess the efficacy and safety of Mircera given intravenously in the treatment of renal anemia in chronic kidney disease patients on dialysis who are not currently receiving epoetin or any other erythropoietic substance. The anticipated time on study treatment is 1-2 years and the target sample size is 100-500 individuals.

Detailed Description

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Conditions

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Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

methoxy polyethylene glycol-epoetin beta [Mircera]

Intervention Type DRUG

0.4 micrograms/kg iv (starting dose) once every 2 weeks

2

Group Type ACTIVE_COMPARATOR

epoetin

Intervention Type DRUG

3 times a week iv, as prescribed.

Interventions

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epoetin

3 times a week iv, as prescribed.

Intervention Type DRUG

methoxy polyethylene glycol-epoetin beta [Mircera]

0.4 micrograms/kg iv (starting dose) once every 2 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients \>=18 years of age;
* chronic renal anemia;
* dialysis therapy for at least 2 weeks before screening.

Exclusion Criteria

* women who are pregnant, breastfeeding or using unreliable birth control methods;
* administration of any investigational drug within 4 weeks before screening.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Davis, California, United States

Site Status

Lakewood, Colorado, United States

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Atlanta, Georgia, United States

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Augusta, Georgia, United States

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New Orleans, Louisiana, United States

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Boston, Massachusetts, United States

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Springfield, Massachusetts, United States

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Detroit, Michigan, United States

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Mineola, New York, United States

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New York, New York, United States

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Toledo, Ohio, United States

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Houston, Texas, United States

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Burlington, Vermont, United States

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Norfolk, Virginia, United States

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Curitiba, , Brazil

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Ribeirão Preto, , Brazil

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São Paulo, , Brazil

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São Paulo, , Brazil

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Calgary, Alberta, Canada

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Vancouver, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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St. John's, Newfoundland and Labrador, Canada

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Kingston, Ontario, Canada

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London, Ontario, Canada

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Toronto, Ontario, Canada

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Montreal, Quebec, Canada

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Saskatoon, Saskatchewan, Canada

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Liberec, , Czechia

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Prague, , Czechia

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Ústí nad Labem, , Czechia

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Alexandroupoli, , Greece

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Larissa, , Greece

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Nikaia, , Greece

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Thessaloniki, , Greece

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Bergen, , Norway

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Oslo, , Norway

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Gdansk, , Poland

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Gdynia, , Poland

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Krakow, , Poland

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Lodz, , Poland

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Poznan, , Poland

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Szczecin, , Poland

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Wołomin, , Poland

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Wroclaw, , Poland

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Moscow, , Russia

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Moscow, , Russia

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Moscow, , Russia

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Saint Petersburg, , Russia

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Saint Petersburg, , Russia

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Johannesburg, , South Africa

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Soweto, , South Africa

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Bilbao, , Spain

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Santander, , Spain

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Karlstad, , Sweden

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Lausanne, , Switzerland

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Bangkok, , Thailand

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Bangkok, , Thailand

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Chiang Mai, , Thailand

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Chon Buri, , Thailand

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Countries

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New Zealand Puerto Rico United States Brazil Canada Czechia Greece Norway Poland Russia South Africa Spain Sweden Switzerland Thailand

References

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Chung EY, Palmer SC, Saglimbene VM, Craig JC, Tonelli M, Strippoli GF. Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis. Cochrane Database Syst Rev. 2023 Feb 13;2(2):CD010590. doi: 10.1002/14651858.CD010590.pub3.

Reference Type DERIVED
PMID: 36791280 (View on PubMed)

Klinger M, Arias M, Vargemezis V, Besarab A, Sulowicz W, Gerntholtz T, Ciechanowski K, Dougherty FC, Beyer U. Efficacy of intravenous methoxy polyethylene glycol-epoetin beta administered every 2 weeks compared with epoetin administered 3 times weekly in patients treated by hemodialysis or peritoneal dialysis: a randomized trial. Am J Kidney Dis. 2007 Dec;50(6):989-1000. doi: 10.1053/j.ajkd.2007.08.013.

Reference Type DERIVED
PMID: 18037099 (View on PubMed)

Other Identifiers

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BA16736

Identifier Type: -

Identifier Source: org_study_id