A Study of Intravenous or Subcutaneous Mircera for the Treatment of Anemia in Dialysis Patients

NCT ID: NCT00081484

Last Updated: 2016-11-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

336 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-06-30

Study Completion Date

2006-03-31

Brief Summary

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This study will assess the efficacy and safety of intravenous (iv) or subcutaneous (sc) Mircera, administered with pre-filled syringes, as maintenance treatment for renal anemia in chronic kidney disease patients on dialysis who were previously receiving iv or sc epoetin. The anticipated time on study treatment is 3-12 months and the target sample size is 100-500 individuals.

Detailed Description

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Conditions

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Anemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

methoxy polyethylene glycol-epoetin beta [Mircera]

Intervention Type DRUG

30, 50 or 90 micrograms iv or sc (starting dose) every 2 weeks

2

Group Type ACTIVE_COMPARATOR

epoetin alfa or beta

Intervention Type DRUG

iv or sc, as prescribed

Interventions

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epoetin alfa or beta

iv or sc, as prescribed

Intervention Type DRUG

methoxy polyethylene glycol-epoetin beta [Mircera]

30, 50 or 90 micrograms iv or sc (starting dose) every 2 weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* adult patients \>=18 years of age;
* chronic renal anemia;
* on dialysis therapy for at least 12 weeks before screening;
* receiving iv or sc epoetin for at least 8 weeks before screening.

Exclusion Criteria

* women who are pregnant, breastfeeding or using unreliable birth control methods;
* administration of another investigational drug within 4 weeks before screening, or during the study period.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hoffmann-La Roche

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Trials

Role: STUDY_DIRECTOR

Hoffmann-La Roche

Locations

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Covina, California, United States

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Los Alamitos, California, United States

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Los Angeles, California, United States

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San Diego, California, United States

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San Diego, California, United States

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Tampa, Florida, United States

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Honolulu, Hawaii, United States

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South Holland, Illinois, United States

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Baton Rouge, Louisiana, United States

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Shreveport, Louisiana, United States

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Shreveport, Louisiana, United States

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Boston, Massachusetts, United States

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Kalamazoo, Michigan, United States

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Columbus, Mississippi, United States

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Tupelo, Mississippi, United States

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St Louis, Missouri, United States

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Hackensack, New Jersey, United States

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Flushing, New York, United States

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New York, New York, United States

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Orchard Park, New York, United States

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Cleveland, Ohio, United States

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Cleveland, Ohio, United States

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Oregon City, Oregon, United States

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Erie, Pennsylvania, United States

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Lewistown, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Columbia, South Carolina, United States

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Charlottesville, Virginia, United States

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Norfolk, Virginia, United States

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Ottawa, Ontario, Canada

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Toronto, Ontario, Canada

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Greenfield Park, Quebec, Canada

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Montreal, Quebec, Canada

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Aix-en-Provence, , France

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Chambéry, , France

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Hyères, , France

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Le Kremlin-Bicêtre, , France

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Nantes, , France

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Paris, , France

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Rouen, , France

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Erlangen, , Germany

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München, , Germany

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Nuremberg, , Germany

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Como, , Italy

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Modena, , Italy

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Pavia, , Italy

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Rzeszów, , Poland

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Warsaw, , Poland

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Carnaxide, , Portugal

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Porto, , Portugal

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Setúbal, , Portugal

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Ponce, , Puerto Rico

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San Juan, , Puerto Rico

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Alicante, , Spain

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Madrid, , Spain

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Kaohsiung City, , Taiwan

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Taichung, , Taiwan

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Taipei, , Taiwan

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Bangkok, , Thailand

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Glasgow, , United Kingdom

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Hertford, , United Kingdom

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London, , United Kingdom

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Salford, , United Kingdom

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Swansea, , United Kingdom

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Countries

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United States Canada France Germany Italy Poland Portugal Puerto Rico Spain Taiwan Thailand United Kingdom

References

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Chung EY, Palmer SC, Saglimbene VM, Craig JC, Tonelli M, Strippoli GF. Erythropoiesis-stimulating agents for anaemia in adults with chronic kidney disease: a network meta-analysis. Cochrane Database Syst Rev. 2023 Feb 13;2(2):CD010590. doi: 10.1002/14651858.CD010590.pub3.

Reference Type DERIVED
PMID: 36791280 (View on PubMed)

Other Identifiers

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BA17284

Identifier Type: -

Identifier Source: org_study_id